Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice

One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in...

Descripción completa

Detalles Bibliográficos
Autores principales: Balsari, A, Rumio, C, Morelli, D, Sfondrini, L, Nardini, E, Barajon, I, Ménard, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364005/
https://www.ncbi.nlm.nih.gov/pubmed/11747341
http://dx.doi.org/10.1054/bjoc.2001.2188
_version_ 1782153846259187712
author Balsari, A
Rumio, C
Morelli, D
Sfondrini, L
Nardini, E
Barajon, I
Ménard, S
author_facet Balsari, A
Rumio, C
Morelli, D
Sfondrini, L
Nardini, E
Barajon, I
Ménard, S
author_sort Balsari, A
collection PubMed
description One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies. © 2001 Cancer Research Campaign http://www.bjcancer.com
format Text
id pubmed-2364005
institution National Center for Biotechnology Information
language English
publishDate 2001
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23640052009-09-10 Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice Balsari, A Rumio, C Morelli, D Sfondrini, L Nardini, E Barajon, I Ménard, S Br J Cancer Regular Article One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-12 /pmc/articles/PMC2364005/ /pubmed/11747341 http://dx.doi.org/10.1054/bjoc.2001.2188 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Balsari, A
Rumio, C
Morelli, D
Sfondrini, L
Nardini, E
Barajon, I
Ménard, S
Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
title Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
title_full Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
title_fullStr Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
title_full_unstemmed Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
title_short Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
title_sort topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364005/
https://www.ncbi.nlm.nih.gov/pubmed/11747341
http://dx.doi.org/10.1054/bjoc.2001.2188
work_keys_str_mv AT balsaria topicaladministrationofadoxorubicinspecificmonoclonalantibodypreventsdruginducedmouthapoptosisinmice
AT rumioc topicaladministrationofadoxorubicinspecificmonoclonalantibodypreventsdruginducedmouthapoptosisinmice
AT morellid topicaladministrationofadoxorubicinspecificmonoclonalantibodypreventsdruginducedmouthapoptosisinmice
AT sfondrinil topicaladministrationofadoxorubicinspecificmonoclonalantibodypreventsdruginducedmouthapoptosisinmice
AT nardinie topicaladministrationofadoxorubicinspecificmonoclonalantibodypreventsdruginducedmouthapoptosisinmice
AT barajoni topicaladministrationofadoxorubicinspecificmonoclonalantibodypreventsdruginducedmouthapoptosisinmice
AT menards topicaladministrationofadoxorubicinspecificmonoclonalantibodypreventsdruginducedmouthapoptosisinmice

Ejemplares similares