The relationship between radiation-induced G(1)arrest and chromosome aberrations in Li-Fraumeni fibroblasts with or without germline TP53 mutations

We previously showed that cultured fibroblasts from patients with the cancer-prone Li-Fraumeni (LF) syndrome, having heterozygous germline TP53 mutations, sustain less ionizing radiation-induced permanent G(1) arrest than normal fibroblasts. In contrast, fibroblast strains from LF patients without T...

Descripción completa

Detalles Bibliográficos
Autores principales: Boyle, J M, Spreadborough, A, Greaves, M J, Birch, J M, Varley, J M, Scott, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364041/
https://www.ncbi.nlm.nih.gov/pubmed/11461092
http://dx.doi.org/10.1054/bjoc.2001.1896

Ejemplares similares

Ejemplares similares