The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer

Expression of vascular endothelial growth factor (VEGF)-C and that of its receptors were assessed in non-small cell lung cancer. Immunohistochemistry revealed positive VEGF-C expression in 38.7% (24/62) of the patients studied. A significant positive correlation was found between VEGF-C in cancer ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Kajita, T, Ohta, Y, Kimura, K, Tamura, M, Tanaka, Y, Tsunezuka, Y, Oda, M, Sasaki, T, Watanabe, Go
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364042/
https://www.ncbi.nlm.nih.gov/pubmed/11461086
http://dx.doi.org/10.1054/bjoc.2001.1882
Descripción
Sumario:Expression of vascular endothelial growth factor (VEGF)-C and that of its receptors were assessed in non-small cell lung cancer. Immunohistochemistry revealed positive VEGF-C expression in 38.7% (24/62) of the patients studied. A significant positive correlation was found between VEGF-C in cancer cells and VEGF receptor-3 (VEGFR-3) in vascular endothelial cells, but not between VEGF-C in cancer cells and VEGFR-2 in endothelial cells. In this cohort of lung cancer patients, VEGF-C expression was significantly associated with lymph node metastasis, lymphatic vessel invasion, and worse outcomes after the operation. Although the independent prognostic impact of VEGF-C and VEGFR-3 was not clear, VEGFR-2 expression in endothelial cells retained the independency as the prognostic indicator. In light of these findings, we conclude that VEGF-C plays an important role in lymphatic invasion/metastasis and tumour progression in non-small cell lung cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com

Ejemplares similares