The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer

Expression of vascular endothelial growth factor (VEGF)-C and that of its receptors were assessed in non-small cell lung cancer. Immunohistochemistry revealed positive VEGF-C expression in 38.7% (24/62) of the patients studied. A significant positive correlation was found between VEGF-C in cancer ce...

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Autores principales: Kajita, T, Ohta, Y, Kimura, K, Tamura, M, Tanaka, Y, Tsunezuka, Y, Oda, M, Sasaki, T, Watanabe, Go
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364042/
https://www.ncbi.nlm.nih.gov/pubmed/11461086
http://dx.doi.org/10.1054/bjoc.2001.1882
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author Kajita, T
Ohta, Y
Kimura, K
Tamura, M
Tanaka, Y
Tsunezuka, Y
Oda, M
Sasaki, T
Watanabe, Go
author_facet Kajita, T
Ohta, Y
Kimura, K
Tamura, M
Tanaka, Y
Tsunezuka, Y
Oda, M
Sasaki, T
Watanabe, Go
author_sort Kajita, T
collection PubMed
description Expression of vascular endothelial growth factor (VEGF)-C and that of its receptors were assessed in non-small cell lung cancer. Immunohistochemistry revealed positive VEGF-C expression in 38.7% (24/62) of the patients studied. A significant positive correlation was found between VEGF-C in cancer cells and VEGF receptor-3 (VEGFR-3) in vascular endothelial cells, but not between VEGF-C in cancer cells and VEGFR-2 in endothelial cells. In this cohort of lung cancer patients, VEGF-C expression was significantly associated with lymph node metastasis, lymphatic vessel invasion, and worse outcomes after the operation. Although the independent prognostic impact of VEGF-C and VEGFR-3 was not clear, VEGFR-2 expression in endothelial cells retained the independency as the prognostic indicator. In light of these findings, we conclude that VEGF-C plays an important role in lymphatic invasion/metastasis and tumour progression in non-small cell lung cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23640422009-09-10 The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer Kajita, T Ohta, Y Kimura, K Tamura, M Tanaka, Y Tsunezuka, Y Oda, M Sasaki, T Watanabe, Go Br J Cancer Regular Article Expression of vascular endothelial growth factor (VEGF)-C and that of its receptors were assessed in non-small cell lung cancer. Immunohistochemistry revealed positive VEGF-C expression in 38.7% (24/62) of the patients studied. A significant positive correlation was found between VEGF-C in cancer cells and VEGF receptor-3 (VEGFR-3) in vascular endothelial cells, but not between VEGF-C in cancer cells and VEGFR-2 in endothelial cells. In this cohort of lung cancer patients, VEGF-C expression was significantly associated with lymph node metastasis, lymphatic vessel invasion, and worse outcomes after the operation. Although the independent prognostic impact of VEGF-C and VEGFR-3 was not clear, VEGFR-2 expression in endothelial cells retained the independency as the prognostic indicator. In light of these findings, we conclude that VEGF-C plays an important role in lymphatic invasion/metastasis and tumour progression in non-small cell lung cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-07 /pmc/articles/PMC2364042/ /pubmed/11461086 http://dx.doi.org/10.1054/bjoc.2001.1882 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Kajita, T
Ohta, Y
Kimura, K
Tamura, M
Tanaka, Y
Tsunezuka, Y
Oda, M
Sasaki, T
Watanabe, Go
The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer
title The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer
title_full The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer
title_fullStr The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer
title_full_unstemmed The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer
title_short The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer
title_sort expression of vascular endothelial growth factor c and its receptors in non-small cell lung cancer
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364042/
https://www.ncbi.nlm.nih.gov/pubmed/11461086
http://dx.doi.org/10.1054/bjoc.2001.1882
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