Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers

Vascular endothelial growth factor (VEGF) has been identified as an important factor for tumour angiogenesis, which is essential for the growth, invasion and metastasis of solid tumours. Significantly increased VEGF level from the primary tumour to the metastatic lesion of ovarian cancers was found...

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Autores principales: Fujimoto, J, Sakaguchi, H, Aoki, I, Khatun, S, Tamaya, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364064/
https://www.ncbi.nlm.nih.gov/pubmed/11487257
http://dx.doi.org/10.1054/bjoc.2001.1933
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author Fujimoto, J
Sakaguchi, H
Aoki, I
Khatun, S
Tamaya, T
author_facet Fujimoto, J
Sakaguchi, H
Aoki, I
Khatun, S
Tamaya, T
author_sort Fujimoto, J
collection PubMed
description Vascular endothelial growth factor (VEGF) has been identified as an important factor for tumour angiogenesis, which is essential for the growth, invasion and metastasis of solid tumours. Significantly increased VEGF level from the primary tumour to the metastatic lesion of ovarian cancers was found in 8 of 30 cases. The 24-month survival rate of the patients with significantly increased VEGF level was extremely poor (0/8 = 0%) in comparison with that of patients with no change in the level (15/22 = 68%) from the primary tumour to the metastatic lesion. This indicates that VEGF may contribute to the advancement of metastatic lesions, and that VEGF level in metastatic lesions may be a prognostic indicator. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23640642009-09-10 Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers Fujimoto, J Sakaguchi, H Aoki, I Khatun, S Tamaya, T Br J Cancer Regular Article Vascular endothelial growth factor (VEGF) has been identified as an important factor for tumour angiogenesis, which is essential for the growth, invasion and metastasis of solid tumours. Significantly increased VEGF level from the primary tumour to the metastatic lesion of ovarian cancers was found in 8 of 30 cases. The 24-month survival rate of the patients with significantly increased VEGF level was extremely poor (0/8 = 0%) in comparison with that of patients with no change in the level (15/22 = 68%) from the primary tumour to the metastatic lesion. This indicates that VEGF may contribute to the advancement of metastatic lesions, and that VEGF level in metastatic lesions may be a prognostic indicator. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-08 /pmc/articles/PMC2364064/ /pubmed/11487257 http://dx.doi.org/10.1054/bjoc.2001.1933 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Fujimoto, J
Sakaguchi, H
Aoki, I
Khatun, S
Tamaya, T
Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
title Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
title_full Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
title_fullStr Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
title_full_unstemmed Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
title_short Clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
title_sort clinical implications of expression of vascular endothelial growth factor in metastatic lesions of ovarian cancers
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364064/
https://www.ncbi.nlm.nih.gov/pubmed/11487257
http://dx.doi.org/10.1054/bjoc.2001.1933
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