CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation

2–18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, C, Nonni, A V, Fulford, L, Merrett, S, Chaggar, R, Eusebi, V, Lakhani, S R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364069/
https://www.ncbi.nlm.nih.gov/pubmed/11487275
http://dx.doi.org/10.1054/bjoc.2001.1869
Descripción
Sumario:2–18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient. © 2001 Cancer Research Campaign http://www.bjcancer.com

Ejemplares similares