CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation

2–18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14...

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Autores principales: Jones, C, Nonni, A V, Fulford, L, Merrett, S, Chaggar, R, Eusebi, V, Lakhani, S R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364069/
https://www.ncbi.nlm.nih.gov/pubmed/11487275
http://dx.doi.org/10.1054/bjoc.2001.1869
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author Jones, C
Nonni, A V
Fulford, L
Merrett, S
Chaggar, R
Eusebi, V
Lakhani, S R
author_facet Jones, C
Nonni, A V
Fulford, L
Merrett, S
Chaggar, R
Eusebi, V
Lakhani, S R
author_sort Jones, C
collection PubMed
description 2–18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23640692009-09-10 CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation Jones, C Nonni, A V Fulford, L Merrett, S Chaggar, R Eusebi, V Lakhani, S R Br J Cancer Regular Article 2–18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-08 /pmc/articles/PMC2364069/ /pubmed/11487275 http://dx.doi.org/10.1054/bjoc.2001.1869 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Jones, C
Nonni, A V
Fulford, L
Merrett, S
Chaggar, R
Eusebi, V
Lakhani, S R
CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
title CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
title_full CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
title_fullStr CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
title_full_unstemmed CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
title_short CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
title_sort cgh analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364069/
https://www.ncbi.nlm.nih.gov/pubmed/11487275
http://dx.doi.org/10.1054/bjoc.2001.1869
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