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The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition

Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Loss of viability following TS inhibition occurs as a consequence of depleted dTTP pools and at least in some cell lines, accumulation of dUTP...

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Detalles Bibliográficos
Autores principales:	Webley, S D, Welsh, S J, Jackman, A L, Aherne, G W
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364072/ https://www.ncbi.nlm.nih.gov/pubmed/11487279 http://dx.doi.org/10.1054/bjoc.2001.1921

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