IL-6 gene amplification and expression in human glioblastomas

The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding sugges...

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Detalles Bibliográficos
Autores principales: Tchirkov, A, Rolhion, C, Bertrand, S, Doré, J-F, Dubost, J-J, Verrelle, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364101/
https://www.ncbi.nlm.nih.gov/pubmed/11506489
http://dx.doi.org/10.1054/bjoc.2001.1942
Descripción
Sumario:The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression. © 2001 Cancer Research Campaign http://www.bjcancer.com

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