IL-6 gene amplification and expression in human glioblastomas

The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding sugges...

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Autores principales: Tchirkov, A, Rolhion, C, Bertrand, S, Doré, J-F, Dubost, J-J, Verrelle, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364101/
https://www.ncbi.nlm.nih.gov/pubmed/11506489
http://dx.doi.org/10.1054/bjoc.2001.1942
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author Tchirkov, A
Rolhion, C
Bertrand, S
Doré, J-F
Dubost, J-J
Verrelle, P
author_facet Tchirkov, A
Rolhion, C
Bertrand, S
Doré, J-F
Dubost, J-J
Verrelle, P
author_sort Tchirkov, A
collection PubMed
description The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23641012009-09-10 IL-6 gene amplification and expression in human glioblastomas Tchirkov, A Rolhion, C Bertrand, S Doré, J-F Dubost, J-J Verrelle, P Br J Cancer Regular Article The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-08 /pmc/articles/PMC2364101/ /pubmed/11506489 http://dx.doi.org/10.1054/bjoc.2001.1942 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Tchirkov, A
Rolhion, C
Bertrand, S
Doré, J-F
Dubost, J-J
Verrelle, P
IL-6 gene amplification and expression in human glioblastomas
title IL-6 gene amplification and expression in human glioblastomas
title_full IL-6 gene amplification and expression in human glioblastomas
title_fullStr IL-6 gene amplification and expression in human glioblastomas
title_full_unstemmed IL-6 gene amplification and expression in human glioblastomas
title_short IL-6 gene amplification and expression in human glioblastomas
title_sort il-6 gene amplification and expression in human glioblastomas
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364101/
https://www.ncbi.nlm.nih.gov/pubmed/11506489
http://dx.doi.org/10.1054/bjoc.2001.1942
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AT verrellep il6geneamplificationandexpressioninhumanglioblastomas

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