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Solid stress facilitates spheroid formation: potential involvement of hyaluronan
When neoplastic cells grow in confined spaces in vivo, they exert a finite force on the surrounding tissue resulting in the generation of solid stress. By growing multicellular spheroids in agarose gels of defined mechanical properties, we have recently shown that solid stress inhibits the growth of...
Autores principales: | Koike, C, McKee, T D, Pluen, A, Ramanujan, S, Burton, K, Munn, L L, Boucher, Y, Jain, R K |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364140/ https://www.ncbi.nlm.nih.gov/pubmed/11953828 http://dx.doi.org/10.1038/sj.bjc.6600158 |
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