Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1

In early breast cancer axillary nodes are usually impalpable and over 50% of such patients may have an axillary clearance when no nodes are involved. This work identifies axillary node status by imaging with a Tc-99m radiolabelled anti-Polymorphic Epithelial Mucin, humanised monoclonal antibody (hum...

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Detalles Bibliográficos
Autores principales: Al-Yasi, A R, Carroll, M J, Ellison, D, Granowska, M, Mather, S J, Wells, C A, Carpenter, R, Britton, K E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364153/
https://www.ncbi.nlm.nih.gov/pubmed/11953817
http://dx.doi.org/10.1038/sj.bjc.6600200
Descripción
Sumario:In early breast cancer axillary nodes are usually impalpable and over 50% of such patients may have an axillary clearance when no nodes are involved. This work identifies axillary node status by imaging with a Tc-99m radiolabelled anti-Polymorphic Epithelial Mucin, humanised monoclonal antibody (human milk fat globule 1), prior to surgery in 30 patients. Change detection analysis of image data with probability mapping is undertaken. A specificity of 93% and positive predictive value of 92% (both 100% if a second cancer in the axilla with negative nodes is considered) were found. A strategy for combining negative imaging with the sentinel node procedure is presented. British Journal of Cancer (2002) 86, 870–878. DOI: 10.1038/sj/bjc/6600200 www.bjcancer.com © 2002 Cancer Research UK

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