Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1

In early breast cancer axillary nodes are usually impalpable and over 50% of such patients may have an axillary clearance when no nodes are involved. This work identifies axillary node status by imaging with a Tc-99m radiolabelled anti-Polymorphic Epithelial Mucin, humanised monoclonal antibody (hum...

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Autores principales: Al-Yasi, A R, Carroll, M J, Ellison, D, Granowska, M, Mather, S J, Wells, C A, Carpenter, R, Britton, K E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364153/
https://www.ncbi.nlm.nih.gov/pubmed/11953817
http://dx.doi.org/10.1038/sj.bjc.6600200
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author Al-Yasi, A R
Carroll, M J
Ellison, D
Granowska, M
Mather, S J
Wells, C A
Carpenter, R
Britton, K E
author_facet Al-Yasi, A R
Carroll, M J
Ellison, D
Granowska, M
Mather, S J
Wells, C A
Carpenter, R
Britton, K E
author_sort Al-Yasi, A R
collection PubMed
description In early breast cancer axillary nodes are usually impalpable and over 50% of such patients may have an axillary clearance when no nodes are involved. This work identifies axillary node status by imaging with a Tc-99m radiolabelled anti-Polymorphic Epithelial Mucin, humanised monoclonal antibody (human milk fat globule 1), prior to surgery in 30 patients. Change detection analysis of image data with probability mapping is undertaken. A specificity of 93% and positive predictive value of 92% (both 100% if a second cancer in the axilla with negative nodes is considered) were found. A strategy for combining negative imaging with the sentinel node procedure is presented. British Journal of Cancer (2002) 86, 870–878. DOI: 10.1038/sj/bjc/6600200 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23641532009-09-10 Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1 Al-Yasi, A R Carroll, M J Ellison, D Granowska, M Mather, S J Wells, C A Carpenter, R Britton, K E Br J Cancer Clinical In early breast cancer axillary nodes are usually impalpable and over 50% of such patients may have an axillary clearance when no nodes are involved. This work identifies axillary node status by imaging with a Tc-99m radiolabelled anti-Polymorphic Epithelial Mucin, humanised monoclonal antibody (human milk fat globule 1), prior to surgery in 30 patients. Change detection analysis of image data with probability mapping is undertaken. A specificity of 93% and positive predictive value of 92% (both 100% if a second cancer in the axilla with negative nodes is considered) were found. A strategy for combining negative imaging with the sentinel node procedure is presented. British Journal of Cancer (2002) 86, 870–878. DOI: 10.1038/sj/bjc/6600200 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-03-18 /pmc/articles/PMC2364153/ /pubmed/11953817 http://dx.doi.org/10.1038/sj.bjc.6600200 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Al-Yasi, A R
Carroll, M J
Ellison, D
Granowska, M
Mather, S J
Wells, C A
Carpenter, R
Britton, K E
Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1
title Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1
title_full Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1
title_fullStr Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1
title_full_unstemmed Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1
title_short Axillary node status in breast cancer patients prior to surgery by imaging with Tc-99m humanised anti-PEM monoclonal antibody, hHMFG1
title_sort axillary node status in breast cancer patients prior to surgery by imaging with tc-99m humanised anti-pem monoclonal antibody, hhmfg1
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364153/
https://www.ncbi.nlm.nih.gov/pubmed/11953817
http://dx.doi.org/10.1038/sj.bjc.6600200
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