Cargando…

Nuclear distribution of porphobilinogen deaminase (PBGD) in glioma cells: a regulatory role in cancer transformation?

Recently, considerable interest has been directed to red-fluorescence photodiagnosis of brain and other tumours during surgery using the protoporphyrin IX natural precursor, 5-aminolaevulinic acid. In the present study we focused on the role of the rate-limiting enzyme porphobilinogen deaminase in g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Greenbaum, L, Gozlan, Y, Schwartz, D, Katcoff, D J, Malik, Z
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2002
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364163/ https://www.ncbi.nlm.nih.gov/pubmed/11953837 http://dx.doi.org/10.1038/sj.bjc.6600173

Ejemplares similares

Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma
por: Ickowicz Schwartz, D, et al.
Publicado: (2004)

A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization?
por: Gibson, S. L., et al.
Publicado: (1998)

Enigmatic Evolutionary History of Porphobilinogen Deaminase in Eukaryotic Phototrophs
por: Oborník, Miroslav
Publicado: (2021)

The crystal structures of the enzyme hydroxymethylbilane synthase, also known as porphobilinogen deaminase
por: Helliwell, John R.
Publicado: (2021)

PORPHOBILINOGEN DEAMINASE Deficiency Alters Vegetative and Reproductive Development and Causes Lesions in Arabidopsis
por: Quesada, Víctor, et al.
Publicado: (2013)

Isolation and Characterization of SPOTTED LEAF42 Encoding a Porphobilinogen Deaminase in Rice
por: Liu, Lin, et al.
Publicado: (2023)

Structural Insights into E. coli Porphobilinogen Deaminase during Synthesis and Exit of 1-Hydroxymethylbilane
por: Bung, Navneet, et al.
Publicado: (2014)

Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism
por: Bustad, Helene J., et al.
Publicado: (2021)

Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Bacillus megaterium
por: Azim, N., et al.
Publicado: (2013)

Host Porphobilinogen Deaminase Deficiency Confers Malaria Resistance in Plasmodium chabaudi but Not in Plasmodium berghei or Plasmodium falciparum During Intraerythrocytic Growth
por: Schnider, Cilly Bernardette, et al.
Publicado: (2020)

Recent Insights into the Pathogenesis of Acute Porphyria Attacks and Increasing Hepatic PBGD as an Etiological Treatment
por: Jericó, Daniel, et al.
Publicado: (2022)

Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution
por: Azim, N., et al.
Publicado: (2014)

AbhemC encoding porphobilinogen deaminase plays an important role in chlorophyll biosynthesis and function in albino Ananas comosus var. bracteatus leaves
por: Xue, Yanbin, et al.
Publicado: (2021)

Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
por: Dubois, L, et al.
Publicado: (2007)

Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts
por: Liu, J, et al.
Publicado: (2007)

Inherent growth advantage of (pre)malignant hepatocytes associated with nuclear translocation of pro-transforming growth factor α
por: Schausberger, E, et al.
Publicado: (2004)

Porphobilinogen Synthase from the Butterfly, Pieris brassicae: Purification and Comparative Characterization
por: Rilk-van Gessel, Roland, et al.
Publicado: (2007)

wALADin Benzimidazoles Differentially Modulate the Function of Porphobilinogen Synthase Orthologs
por: Lentz, Christian S., et al.
Publicado: (2014)

Normal reference ranges for urinary δ‐aminolevulinic acid and porphobilinogen levels
por: Agarwal, Sagar, et al.
Publicado: (2020)

Strain engineering and bioprocessing strategies for biobased production of porphobilinogen in Escherichia coli
por: Lall, Davinder, et al.
Publicado: (2021)

ALAD Inhibition by Porphobilinogen Rationalizes the Accumulation of δ-Aminolevulinate in Acute Porphyrias
por: San Juan, Itxaso, et al.
Publicado: (2022)

Short communication: A33scFv–cytosine deaminase: a recombinant protein construct for antibody-directed enzyme-prodrug therapy
por: Deckert, P M, et al.
Publicado: (2003)

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines
por: Mohammed, M Z, et al.
Publicado: (2011)

Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer
por: Bollivar, David W, et al.
Publicado: (2004)

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs
por: Ashley, D M, et al.
Publicado: (2008)

In silico designing and molecular docking of a potent analog against Staphylococcus aureus porphobilinogen synthase
por: Kumar, Pasupuleti Santhosh, et al.
Publicado: (2014)

Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expression in rat glioma cells
por: González, A, et al.
Publicado: (2007)

Depth distributions of bacteria for the Pseudomonas aeruginosa-infected burn wounds treated by methylene blue-mediated photodynamic therapy in rats: effects of additives to photosensitizer
por: Sarker, Roma R., et al.
Publicado: (2022)

Cell migration in paediatric glioma; characterisation and potential therapeutic targeting
por: Cockle, J V, et al.
Publicado: (2015)

Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1
por: Bertrand, Y, et al.
Publicado: (2011)

Impaired TNFα-induced A20 expression in E1A/Ras-transformed cells
por: Huang, H-L, et al.
Publicado: (2009)

Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts
por: Geoerger, B, et al.
Publicado: (2003)

Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin
por: Sasaki, T, et al.
Publicado: (2002)

Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
por: Kanzawa, T, et al.
Publicado: (2003)

Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids
por: Günther, W, et al.
Publicado: (2003)

The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer
por: Ward, S T, et al.
Publicado: (2015)

Variation in mitochondrial function in hypoxia-sensitive and hypoxia-tolerant human glioma cells
por: Turcotte, M L, et al.
Publicado: (2002)

The impact of regulatory T cells on carcinogen-induced sarcogenesis
por: Betts, G, et al.
Publicado: (2007)

Protein expression in experimental malignant glioma varies over time and is altered by radiotherapy treatment
por: Wibom, C, et al.
Publicado: (2006)

Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice
por: Leuraud, P, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_fcftv7ar4boip0ve41q69od5pp