Translation initiation and its deregulation during tumorigenesis

Regulation of protein synthesis at the level of translation initiation is fundamentally important for the control of cell proliferation under normal physiological conditions. Conversely, misregulation of protein synthesis is emerging as a major contributory factor in cancer development. Most bulk pr...

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Detalles Bibliográficos
Autores principales: Watkins, S J, Norbury, C J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364173/
https://www.ncbi.nlm.nih.gov/pubmed/11953842
http://dx.doi.org/10.1038/sj.bjc.6600222
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author Watkins, S J
Norbury, C J
author_facet Watkins, S J
Norbury, C J
author_sort Watkins, S J
collection PubMed
description Regulation of protein synthesis at the level of translation initiation is fundamentally important for the control of cell proliferation under normal physiological conditions. Conversely, misregulation of protein synthesis is emerging as a major contributory factor in cancer development. Most bulk protein synthesis is initiated via recognition of the mRNA 5′ cap and subsequent recognition of the initiator AUG codon by a directional scanning mechanism. However, several key regulators of tumour development are translated by a cap-independent pathway. Here we review eukaryotic translation initiation, its regulation and the ways in which this regulation can break down during tumorigenesis. British Journal of Cancer (2002) 86, 1023–1027. DOI: 10.1038/sj/bjc/6600222 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23641732009-09-10 Translation initiation and its deregulation during tumorigenesis Watkins, S J Norbury, C J Br J Cancer Minireview Regulation of protein synthesis at the level of translation initiation is fundamentally important for the control of cell proliferation under normal physiological conditions. Conversely, misregulation of protein synthesis is emerging as a major contributory factor in cancer development. Most bulk protein synthesis is initiated via recognition of the mRNA 5′ cap and subsequent recognition of the initiator AUG codon by a directional scanning mechanism. However, several key regulators of tumour development are translated by a cap-independent pathway. Here we review eukaryotic translation initiation, its regulation and the ways in which this regulation can break down during tumorigenesis. British Journal of Cancer (2002) 86, 1023–1027. DOI: 10.1038/sj/bjc/6600222 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-04-08 /pmc/articles/PMC2364173/ /pubmed/11953842 http://dx.doi.org/10.1038/sj.bjc.6600222 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Watkins, S J
Norbury, C J
Translation initiation and its deregulation during tumorigenesis
title Translation initiation and its deregulation during tumorigenesis
title_full Translation initiation and its deregulation during tumorigenesis
title_fullStr Translation initiation and its deregulation during tumorigenesis
title_full_unstemmed Translation initiation and its deregulation during tumorigenesis
title_short Translation initiation and its deregulation during tumorigenesis
title_sort translation initiation and its deregulation during tumorigenesis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364173/
https://www.ncbi.nlm.nih.gov/pubmed/11953842
http://dx.doi.org/10.1038/sj.bjc.6600222
work_keys_str_mv AT watkinssj translationinitiationanditsderegulationduringtumorigenesis
AT norburycj translationinitiationanditsderegulationduringtumorigenesis

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