Gallstones, cholecystectomy, and the risk for developing pancreatic cancer

We examined the relation between gallstones, cholecystectomy, and the development of pancreatic cancer in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 104 856 women and 48 928 men without cancer at baseline, we documented 349 cases of pancreatic cancer during up...

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Autores principales: Schernhammer, E S, Michaud, D S, Leitzmann, M F, Giovannucci, E, Colditz, G A, Fuchs, C S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364180/
https://www.ncbi.nlm.nih.gov/pubmed/11953853
http://dx.doi.org/10.1038/sj.bjc.6600193
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author Schernhammer, E S
Michaud, D S
Leitzmann, M F
Giovannucci, E
Colditz, G A
Fuchs, C S
author_facet Schernhammer, E S
Michaud, D S
Leitzmann, M F
Giovannucci, E
Colditz, G A
Fuchs, C S
author_sort Schernhammer, E S
collection PubMed
description We examined the relation between gallstones, cholecystectomy, and the development of pancreatic cancer in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 104 856 women and 48 928 men without cancer at baseline, we documented 349 cases of pancreatic cancer during up to 16 years of follow-up. Participants were classified according to a history of gallstones or cholecystectomy. The age-adjusted relative risk of pancreatic cancer following cholecystectomy or diagnosis of gallstones was 1.31 (95% CI, 0.93–1.83). However, adjustment for other pancreatic cancer risk factors attenuated the association (RR=1.11, 95% CI, 0.78–1.56); this risk did not increase with increasing time following cholecystectomy or gallstones. Gallstones or cholecystectomy do not appear to be significant risk factors for pancreatic cancer. British Journal of Cancer (2002) 86, 1081–1084. DOI: 10.1038/sj/bjc/6600193 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23641802009-09-10 Gallstones, cholecystectomy, and the risk for developing pancreatic cancer Schernhammer, E S Michaud, D S Leitzmann, M F Giovannucci, E Colditz, G A Fuchs, C S Br J Cancer Epidemiology We examined the relation between gallstones, cholecystectomy, and the development of pancreatic cancer in the Nurses' Health Study and the Health Professionals Follow-up Study. Among 104 856 women and 48 928 men without cancer at baseline, we documented 349 cases of pancreatic cancer during up to 16 years of follow-up. Participants were classified according to a history of gallstones or cholecystectomy. The age-adjusted relative risk of pancreatic cancer following cholecystectomy or diagnosis of gallstones was 1.31 (95% CI, 0.93–1.83). However, adjustment for other pancreatic cancer risk factors attenuated the association (RR=1.11, 95% CI, 0.78–1.56); this risk did not increase with increasing time following cholecystectomy or gallstones. Gallstones or cholecystectomy do not appear to be significant risk factors for pancreatic cancer. British Journal of Cancer (2002) 86, 1081–1084. DOI: 10.1038/sj/bjc/6600193 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-04-08 /pmc/articles/PMC2364180/ /pubmed/11953853 http://dx.doi.org/10.1038/sj.bjc.6600193 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Schernhammer, E S
Michaud, D S
Leitzmann, M F
Giovannucci, E
Colditz, G A
Fuchs, C S
Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
title Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
title_full Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
title_fullStr Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
title_full_unstemmed Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
title_short Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
title_sort gallstones, cholecystectomy, and the risk for developing pancreatic cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364180/
https://www.ncbi.nlm.nih.gov/pubmed/11953853
http://dx.doi.org/10.1038/sj.bjc.6600193
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