Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells

There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin αvβ6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the β6 integrin subunit and...

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Autores principales: Gu, X, Niu, J, Dorahy, D J, Scott, R, Agrez, M V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364215/
https://www.ncbi.nlm.nih.gov/pubmed/12177807
http://dx.doi.org/10.1038/sj.bjc.6600480
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author Gu, X
Niu, J
Dorahy, D J
Scott, R
Agrez, M V
author_facet Gu, X
Niu, J
Dorahy, D J
Scott, R
Agrez, M V
author_sort Gu, X
collection PubMed
description There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin αvβ6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the β6 integrin subunit and extracellular signal-regulated kinase 2. Targetting either β6 or its interaction with extracellular signal-regulated kinase in order to inhibit matrix metalloproteinase activity may offer a useful therapeutic approach in preventing growth and spread of colon cancer. British Journal of Cancer (2002) 87, 348–351. doi:10.1038/sj.bjc.6600480 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23642152009-09-10 Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells Gu, X Niu, J Dorahy, D J Scott, R Agrez, M V Br J Cancer Experimental Therapeutics There is general consensus that matrix metalloproteinases are involved in tumour progression. We show herein that inhibition of integrin αvβ6 expression in colon cancer cells suppresses MMP-9 secretion. This integrin-mediated event is dependent upon direct binding between the β6 integrin subunit and extracellular signal-regulated kinase 2. Targetting either β6 or its interaction with extracellular signal-regulated kinase in order to inhibit matrix metalloproteinase activity may offer a useful therapeutic approach in preventing growth and spread of colon cancer. British Journal of Cancer (2002) 87, 348–351. doi:10.1038/sj.bjc.6600480 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-07-29 2002-08-01 /pmc/articles/PMC2364215/ /pubmed/12177807 http://dx.doi.org/10.1038/sj.bjc.6600480 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Gu, X
Niu, J
Dorahy, D J
Scott, R
Agrez, M V
Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
title Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
title_full Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
title_fullStr Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
title_full_unstemmed Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
title_short Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
title_sort integrin αvβ6-associated erk2 mediates mmp-9 secretion in colon cancer cells
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364215/
https://www.ncbi.nlm.nih.gov/pubmed/12177807
http://dx.doi.org/10.1038/sj.bjc.6600480
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AT scottr integrinavb6associatederk2mediatesmmp9secretionincoloncancercells
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