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Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc

The thyroid TRK-T3 oncogene, produced by a chromosomal translocation, is a chimeric, constitutively activated version of the NTRK1/NGF receptor and it is able to transform NIH3T3 cells and differentiate PC12 cells. TRK-T3 oncoprotein triggers multiple signal transduction pathways. Among others, TRK-...

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Detalles Bibliográficos
Autores principales: Roccato, E, Miranda, C, Ranzi, V, Gishizki, M, Pierotti, M A, Greco, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364237/
https://www.ncbi.nlm.nih.gov/pubmed/12237775
http://dx.doi.org/10.1038/sj.bjc.6600544