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The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis

In order to determine whether angiogenesis is a prognostic marker in lung cancer, we performed a systematic review of the literature to assess the prognostic value on survival of microvessel count in patients with lung cancer. Published studies were identified by an electronic search in order to agg...

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Detalles Bibliográficos
Autores principales: Meert, A-P, Paesmans, M, Martin, B, Delmotte, P, Berghmans, T, Verdebout, J-M, Lafitte, J-J, Mascaux, C, Sculier, J-P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364252/
https://www.ncbi.nlm.nih.gov/pubmed/12232748
http://dx.doi.org/10.1038/sj.bjc.6600551
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author Meert, A-P
Paesmans, M
Martin, B
Delmotte, P
Berghmans, T
Verdebout, J-M
Lafitte, J-J
Mascaux, C
Sculier, J-P
author_facet Meert, A-P
Paesmans, M
Martin, B
Delmotte, P
Berghmans, T
Verdebout, J-M
Lafitte, J-J
Mascaux, C
Sculier, J-P
author_sort Meert, A-P
collection PubMed
description In order to determine whether angiogenesis is a prognostic marker in lung cancer, we performed a systematic review of the literature to assess the prognostic value on survival of microvessel count in patients with lung cancer. Published studies were identified by an electronic search in order to aggregate survival results, after a methodological assessment using a quality scale designed by the European Lung Cancer Working Party. To be eligible, a study had to deal with microvessel count assessment in lung cancer patients on the primary site and to provide survival analysis according to microvessel count expression. Microvessel count has been assessed on surgical samples by immunohistochemistry using factor VIII in 14 studies, CD34 in 10 and CD31 in eight. Respectively 1866, 1440 and 1093 non-small cell lung cancer patients were considered. The overall median quality scores were respectively 52, 59 and 59% for studies assessing microvessel count via factor VIII, CD34 and CD31, without significant difference between studies evaluable or not for meta-analysis nor between studies with significant or non significant results. Seven ‘factor VIII’ studies, nine ‘CD34’ and seven ‘CD31’ provided sufficient data allowing a meta-analysis on survival and were evaluable for results aggregation. This showed that a high microvessel count in the primitive lung tumour was a statistically significant poor prognostic factor for survival in non small cell lung cancer whatever it was assessed by factor VIII (HR: 1.81; 95% CI: 1.16–2.84), CD34 (HR: 1.99; 95% CI: 1.53–2.58) or CD31 (HR: 1.80; 95% CI: 1.10–2.96). Variations in survival among the individual studies can be explained in addition to patients selection criteria by the heterogeneous methodologies used to stain and count microvessels: different antibody clones, identification of ‘hotspots’, Weidner or Chalkey counting method, cut-off selection. Microvessel count, reflecting the angiogenesis, appears to be a poor prognostic factor for survival in surgically treated non small cell lung cancer but standardisation of angiogenesis assessment by the microvessel count is necessary. British Journal of Cancer (2002) 87, 694–701. doi:10.1038/sj.bjc.6600551 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23642522009-09-10 The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis Meert, A-P Paesmans, M Martin, B Delmotte, P Berghmans, T Verdebout, J-M Lafitte, J-J Mascaux, C Sculier, J-P Br J Cancer Review In order to determine whether angiogenesis is a prognostic marker in lung cancer, we performed a systematic review of the literature to assess the prognostic value on survival of microvessel count in patients with lung cancer. Published studies were identified by an electronic search in order to aggregate survival results, after a methodological assessment using a quality scale designed by the European Lung Cancer Working Party. To be eligible, a study had to deal with microvessel count assessment in lung cancer patients on the primary site and to provide survival analysis according to microvessel count expression. Microvessel count has been assessed on surgical samples by immunohistochemistry using factor VIII in 14 studies, CD34 in 10 and CD31 in eight. Respectively 1866, 1440 and 1093 non-small cell lung cancer patients were considered. The overall median quality scores were respectively 52, 59 and 59% for studies assessing microvessel count via factor VIII, CD34 and CD31, without significant difference between studies evaluable or not for meta-analysis nor between studies with significant or non significant results. Seven ‘factor VIII’ studies, nine ‘CD34’ and seven ‘CD31’ provided sufficient data allowing a meta-analysis on survival and were evaluable for results aggregation. This showed that a high microvessel count in the primitive lung tumour was a statistically significant poor prognostic factor for survival in non small cell lung cancer whatever it was assessed by factor VIII (HR: 1.81; 95% CI: 1.16–2.84), CD34 (HR: 1.99; 95% CI: 1.53–2.58) or CD31 (HR: 1.80; 95% CI: 1.10–2.96). Variations in survival among the individual studies can be explained in addition to patients selection criteria by the heterogeneous methodologies used to stain and count microvessels: different antibody clones, identification of ‘hotspots’, Weidner or Chalkey counting method, cut-off selection. Microvessel count, reflecting the angiogenesis, appears to be a poor prognostic factor for survival in surgically treated non small cell lung cancer but standardisation of angiogenesis assessment by the microvessel count is necessary. British Journal of Cancer (2002) 87, 694–701. doi:10.1038/sj.bjc.6600551 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-09-23 2002-09-23 /pmc/articles/PMC2364252/ /pubmed/12232748 http://dx.doi.org/10.1038/sj.bjc.6600551 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Meert, A-P
Paesmans, M
Martin, B
Delmotte, P
Berghmans, T
Verdebout, J-M
Lafitte, J-J
Mascaux, C
Sculier, J-P
The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
title The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
title_full The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
title_fullStr The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
title_full_unstemmed The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
title_short The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
title_sort role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364252/
https://www.ncbi.nlm.nih.gov/pubmed/12232748
http://dx.doi.org/10.1038/sj.bjc.6600551
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