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Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis
Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with exp...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364272/ https://www.ncbi.nlm.nih.gov/pubmed/12232760 http://dx.doi.org/10.1038/sj.bjc.6600507 |
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author | Løvig, T Andersen, S N Thorstensen, L Diep, C B Meling, G I Lothe, R A Rognum, T O |
author_facet | Løvig, T Andersen, S N Thorstensen, L Diep, C B Meling, G I Lothe, R A Rognum, T O |
author_sort | Løvig, T |
collection | PubMed |
description | Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antigens on their tumour cells. In this study, the expression of HLA-DR antigen was investigated by immunohistochemistry in 357 large bowel carcinomas stratified by microsatellite instability status. Sixteen per cent of the tumours showed strong HLA-DR expression and 35% had weak DR expression. We confirmed that patients with strong positive HLA-DR staining had improved survival (P<0.001) compared to patients with no HLA-DR expression. Strong epithelial HLA-DR staining was significantly associated with high level of microsatellite instability (P<0.001). In the subgroup of tumours with characteristics typical of the chromosomal instability phenotype, i.e. in microsatellite-stable tumours, the patients positive for the HLA-DR determinants showed better survival than those without HLA-DR expression. The protective effect of HLA-DR expression on survival was confirmed by multivariate analysis, both in the whole patient group and in the microsatellite-stable/microsatellite instability-low group. This might be explained by enhanced T-cell mediated anti-tumour immune responses against tumour cells in the HLA-DR positive tumours. The finding of better patient survival in the subgroup of strong HLA-DR positive microsatellite-stable tumours may have clinical implications for these patients. British Journal of Cancer (2002) 87, 756–762. doi:10.1038/sj.bjc.6600507 www.bjcancer.com © 2002 Cancer Research UK |
format | Text |
id | pubmed-2364272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23642722009-09-10 Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis Løvig, T Andersen, S N Thorstensen, L Diep, C B Meling, G I Lothe, R A Rognum, T O Br J Cancer Molecular and Cellular Pathology Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antigens on their tumour cells. In this study, the expression of HLA-DR antigen was investigated by immunohistochemistry in 357 large bowel carcinomas stratified by microsatellite instability status. Sixteen per cent of the tumours showed strong HLA-DR expression and 35% had weak DR expression. We confirmed that patients with strong positive HLA-DR staining had improved survival (P<0.001) compared to patients with no HLA-DR expression. Strong epithelial HLA-DR staining was significantly associated with high level of microsatellite instability (P<0.001). In the subgroup of tumours with characteristics typical of the chromosomal instability phenotype, i.e. in microsatellite-stable tumours, the patients positive for the HLA-DR determinants showed better survival than those without HLA-DR expression. The protective effect of HLA-DR expression on survival was confirmed by multivariate analysis, both in the whole patient group and in the microsatellite-stable/microsatellite instability-low group. This might be explained by enhanced T-cell mediated anti-tumour immune responses against tumour cells in the HLA-DR positive tumours. The finding of better patient survival in the subgroup of strong HLA-DR positive microsatellite-stable tumours may have clinical implications for these patients. British Journal of Cancer (2002) 87, 756–762. doi:10.1038/sj.bjc.6600507 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-09-23 2002-09-23 /pmc/articles/PMC2364272/ /pubmed/12232760 http://dx.doi.org/10.1038/sj.bjc.6600507 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Molecular and Cellular Pathology Løvig, T Andersen, S N Thorstensen, L Diep, C B Meling, G I Lothe, R A Rognum, T O Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis |
title | Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis |
title_full | Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis |
title_fullStr | Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis |
title_full_unstemmed | Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis |
title_short | Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis |
title_sort | strong hla-dr expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis |
topic | Molecular and Cellular Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364272/ https://www.ncbi.nlm.nih.gov/pubmed/12232760 http://dx.doi.org/10.1038/sj.bjc.6600507 |
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