Effect of nonsteroidal anti-inflammatory drugs on β-catenin protein levels and catenin-related transcription in human colorectal cancer cells

Elevated β-catenin levels in human colorectal cancer (CRC) cells lead to increased trans-activation of ‘protumorigenic’ β-catenin/T-cell factor (TCF) target genes such as cyclin D1. Therefore, possible targets for the anti-CRC activity of nonsteroidal anti-inflammatory drugs (NSAIDs) are β-catenin a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gardner, S H, Hawcroft, G, Hull, M A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364748/
https://www.ncbi.nlm.nih.gov/pubmed/15188006
http://dx.doi.org/10.1038/sj.bjc.6601901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364748/
https://www.ncbi.nlm.nih.gov/pubmed/15188006
http://dx.doi.org/10.1038/sj.bjc.6601901

Ejemplares similares