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Downregulation of Bcl-2 sensitises interferon-resistant renal cancer cells to Fas

Interferon α (IFNα) is used to treat patients with advanced renal cell carcinoma (RCC) despite limited clinical benefit. IFNα can induce Fas receptor-mediated apoptosis by direct activation of pro-caspase-8 followed by activation of caspase-3. Alternative, indirect activation of caspase-3 via mitoch...

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Detalles Bibliográficos
Autores principales:	Kelly, J D, Dai, J, Eschwege, P, Goldberg, J S, Duggan, B P, Williamson, K E, Bander, N H, Nanus, D M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364752/ https://www.ncbi.nlm.nih.gov/pubmed/15188008 http://dx.doi.org/10.1038/sj.bjc.6601895

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