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UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer

SN-38 is the active metabolite of irinotecan and it is metabolised through conjugation by uridine diphosphate glucuronosyl transferase (UGT1A1). The major toxicity of irinotecan therapy is diarrhoea, which has been related to the enzymatic activity of UGT1A1. We examined the influence of the UGT1A1...

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Detalles Bibliográficos
Autores principales:	Marcuello, E, Altés, A, Menoyo, A, del Rio, E, Gómez-Pardo, M, Baiget, M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364770/ https://www.ncbi.nlm.nih.gov/pubmed/15280927 http://dx.doi.org/10.1038/sj.bjc.6602042

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