The relationship between aberrant methylation and survival in non-small-cell lung cancers

The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significant...

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Detalles Bibliográficos
Autores principales: Toyooka, S, Suzuki, M, Maruyama, R, Toyooka, K O, Tsukuda, K, Fukuyama, Y, Iizasa, T, Aoe, M, Date, H, Fujisawa, T, Shimizu, N, Gazdar, A F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364802/
https://www.ncbi.nlm.nih.gov/pubmed/15266335
http://dx.doi.org/10.1038/sj.bjc.6602013
Descripción
Sumario:The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.

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