The relationship between aberrant methylation and survival in non-small-cell lung cancers

The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significant...

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Autores principales: Toyooka, S, Suzuki, M, Maruyama, R, Toyooka, K O, Tsukuda, K, Fukuyama, Y, Iizasa, T, Aoe, M, Date, H, Fujisawa, T, Shimizu, N, Gazdar, A F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364802/
https://www.ncbi.nlm.nih.gov/pubmed/15266335
http://dx.doi.org/10.1038/sj.bjc.6602013
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author Toyooka, S
Suzuki, M
Maruyama, R
Toyooka, K O
Tsukuda, K
Fukuyama, Y
Iizasa, T
Aoe, M
Date, H
Fujisawa, T
Shimizu, N
Gazdar, A F
author_facet Toyooka, S
Suzuki, M
Maruyama, R
Toyooka, K O
Tsukuda, K
Fukuyama, Y
Iizasa, T
Aoe, M
Date, H
Fujisawa, T
Shimizu, N
Gazdar, A F
author_sort Toyooka, S
collection PubMed
description The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.
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spelling pubmed-23648022009-09-10 The relationship between aberrant methylation and survival in non-small-cell lung cancers Toyooka, S Suzuki, M Maruyama, R Toyooka, K O Tsukuda, K Fukuyama, Y Iizasa, T Aoe, M Date, H Fujisawa, T Shimizu, N Gazdar, A F Br J Cancer Genetics and Genomics The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas. Nature Publishing Group 2004-08-16 2004-07-20 /pmc/articles/PMC2364802/ /pubmed/15266335 http://dx.doi.org/10.1038/sj.bjc.6602013 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Toyooka, S
Suzuki, M
Maruyama, R
Toyooka, K O
Tsukuda, K
Fukuyama, Y
Iizasa, T
Aoe, M
Date, H
Fujisawa, T
Shimizu, N
Gazdar, A F
The relationship between aberrant methylation and survival in non-small-cell lung cancers
title The relationship between aberrant methylation and survival in non-small-cell lung cancers
title_full The relationship between aberrant methylation and survival in non-small-cell lung cancers
title_fullStr The relationship between aberrant methylation and survival in non-small-cell lung cancers
title_full_unstemmed The relationship between aberrant methylation and survival in non-small-cell lung cancers
title_short The relationship between aberrant methylation and survival in non-small-cell lung cancers
title_sort relationship between aberrant methylation and survival in non-small-cell lung cancers
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364802/
https://www.ncbi.nlm.nih.gov/pubmed/15266335
http://dx.doi.org/10.1038/sj.bjc.6602013
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