Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia

Diphenylantimony(III) and diorganotin(IV) derivatives of dithiophosphorus ligands, i.e. Ph(2)SbS(2)PR′(2) (R′ = Ph, OPr-i) and R(2)Sn(S(2)PR′(2))(2) (R = n-Bu, Ph, R′ = Ph; R = Ph, R′ = OPr-i), have been screened against P388 leukemia in mice. All the compounds showed marginal activity towards this...

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Detalles Bibliográficos
Autores principales: Keppler, Bernhard K., Silvestru, Cristian, Haiduc, Ionel
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364873/
https://www.ncbi.nlm.nih.gov/pubmed/18476218
http://dx.doi.org/10.1155/MBD.1994.73
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author Keppler, Bernhard K.
Silvestru, Cristian
Haiduc, Ionel
author_facet Keppler, Bernhard K.
Silvestru, Cristian
Haiduc, Ionel
author_sort Keppler, Bernhard K.
collection PubMed
description Diphenylantimony(III) and diorganotin(IV) derivatives of dithiophosphorus ligands, i.e. Ph(2)SbS(2)PR′(2) (R′ = Ph, OPr-i) and R(2)Sn(S(2)PR′(2))(2) (R = n-Bu, Ph, R′ = Ph; R = Ph, R′ = OPr-i), have been screened against P388 leukemia in mice. All the compounds showed marginal activity towards this tumor system, some of them increasing the life span of the animals with more than 20%. The best results were obtained with (di-iso-propylphosphorodithioato)diphenylantimony(III) which exhibited a T/C value of 136%, at a dose of 5 mg/kg, administered on days 1,2 and 3 after tumor transplantation.
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spelling pubmed-23648732008-05-12 Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia Keppler, Bernhard K. Silvestru, Cristian Haiduc, Ionel Met Based Drugs Research Article Diphenylantimony(III) and diorganotin(IV) derivatives of dithiophosphorus ligands, i.e. Ph(2)SbS(2)PR′(2) (R′ = Ph, OPr-i) and R(2)Sn(S(2)PR′(2))(2) (R = n-Bu, Ph, R′ = Ph; R = Ph, R′ = OPr-i), have been screened against P388 leukemia in mice. All the compounds showed marginal activity towards this tumor system, some of them increasing the life span of the animals with more than 20%. The best results were obtained with (di-iso-propylphosphorodithioato)diphenylantimony(III) which exhibited a T/C value of 136%, at a dose of 5 mg/kg, administered on days 1,2 and 3 after tumor transplantation. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364873/ /pubmed/18476218 http://dx.doi.org/10.1155/MBD.1994.73 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Keppler, Bernhard K.
Silvestru, Cristian
Haiduc, Ionel
Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia
title Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia
title_full Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia
title_fullStr Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia
title_full_unstemmed Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia
title_short Antitumour Organometallics. III. In Vivo Activity of Diphenylantimony(III) and Diorganotin(IV) Dithiophosphorus Derivatives Against P388 Leukemia
title_sort antitumour organometallics. iii. in vivo activity of diphenylantimony(iii) and diorganotin(iv) dithiophosphorus derivatives against p388 leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364873/
https://www.ncbi.nlm.nih.gov/pubmed/18476218
http://dx.doi.org/10.1155/MBD.1994.73
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