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Interactions Between Zinc and Thymulin

Thymulin (formerly called "Facteur Thymique Sérique or FTS) is a metallopeptidic hormone selectively produced by thymic epithelial cells (TEC) and known to induce intra and extra-thymic T cell differentiation. It was initially isolated from porcine serum and shown to be present in calf thymus e...

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Autores principales: Dardenne, Mireille, Pleau, Jean-Marie
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364880/
https://www.ncbi.nlm.nih.gov/pubmed/18476235
http://dx.doi.org/10.1155/MBD.1994.233
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author Dardenne, Mireille
Pleau, Jean-Marie
author_facet Dardenne, Mireille
Pleau, Jean-Marie
author_sort Dardenne, Mireille
collection PubMed
description Thymulin (formerly called "Facteur Thymique Sérique or FTS) is a metallopeptidic hormone selectively produced by thymic epithelial cells (TEC) and known to induce intra and extra-thymic T cell differentiation. It was initially isolated from porcine serum and shown to be present in calf thymus extract. Its amino-acid sequence was determined (<Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn). It is a nonapeptide whose biological activity is dependent on the presence of zinc, in an equimolecular ratio. The metallopeptide thus formed bears a specific tridimensional conformation detected by nuclear magnetic resonance studies, and that yielded a new monoclonal antibody-defined epitope. The presence of zinc and metallothionein has been demonstrated within TEC which produce the peptide, suggesting that the molecule is secreted in its active zinc-containing form. The zinc/thymulin relationship, was further studied using various models of mild zinc deficiency in experimental animals and in humans. Serum thymulin activity was decreased as a result of zinc deficiency, and was corrected by in vivo and in vitro zinc supplementation, suggesting that this parameter could be a sensitive indicator of zinc deficiency. When considered together with the parallel variations seen in T-cell subpopulations and lymphokine production, these observations could provide a possible explanation of the role of zinc on T cell functions.
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spelling pubmed-23648802008-05-12 Interactions Between Zinc and Thymulin Dardenne, Mireille Pleau, Jean-Marie Met Based Drugs Research Article Thymulin (formerly called "Facteur Thymique Sérique or FTS) is a metallopeptidic hormone selectively produced by thymic epithelial cells (TEC) and known to induce intra and extra-thymic T cell differentiation. It was initially isolated from porcine serum and shown to be present in calf thymus extract. Its amino-acid sequence was determined (<Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn). It is a nonapeptide whose biological activity is dependent on the presence of zinc, in an equimolecular ratio. The metallopeptide thus formed bears a specific tridimensional conformation detected by nuclear magnetic resonance studies, and that yielded a new monoclonal antibody-defined epitope. The presence of zinc and metallothionein has been demonstrated within TEC which produce the peptide, suggesting that the molecule is secreted in its active zinc-containing form. The zinc/thymulin relationship, was further studied using various models of mild zinc deficiency in experimental animals and in humans. Serum thymulin activity was decreased as a result of zinc deficiency, and was corrected by in vivo and in vitro zinc supplementation, suggesting that this parameter could be a sensitive indicator of zinc deficiency. When considered together with the parallel variations seen in T-cell subpopulations and lymphokine production, these observations could provide a possible explanation of the role of zinc on T cell functions. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364880/ /pubmed/18476235 http://dx.doi.org/10.1155/MBD.1994.233 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dardenne, Mireille
Pleau, Jean-Marie
Interactions Between Zinc and Thymulin
title Interactions Between Zinc and Thymulin
title_full Interactions Between Zinc and Thymulin
title_fullStr Interactions Between Zinc and Thymulin
title_full_unstemmed Interactions Between Zinc and Thymulin
title_short Interactions Between Zinc and Thymulin
title_sort interactions between zinc and thymulin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364880/
https://www.ncbi.nlm.nih.gov/pubmed/18476235
http://dx.doi.org/10.1155/MBD.1994.233
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