Cargando…
Interactions Between Zinc and Thymulin
Thymulin (formerly called "Facteur Thymique Sérique or FTS) is a metallopeptidic hormone selectively produced by thymic epithelial cells (TEC) and known to induce intra and extra-thymic T cell differentiation. It was initially isolated from porcine serum and shown to be present in calf thymus e...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1994
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364880/ https://www.ncbi.nlm.nih.gov/pubmed/18476235 http://dx.doi.org/10.1155/MBD.1994.233 |
_version_ | 1782154033360797696 |
---|---|
author | Dardenne, Mireille Pleau, Jean-Marie |
author_facet | Dardenne, Mireille Pleau, Jean-Marie |
author_sort | Dardenne, Mireille |
collection | PubMed |
description | Thymulin (formerly called "Facteur Thymique Sérique or FTS) is a metallopeptidic hormone selectively produced by thymic epithelial cells (TEC) and known to induce intra and extra-thymic T cell differentiation. It was initially isolated from porcine serum and shown to be present in calf thymus extract. Its amino-acid sequence was determined (<Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn). It is a nonapeptide whose biological activity is dependent on the presence of zinc, in an equimolecular ratio. The metallopeptide thus formed bears a specific tridimensional conformation detected by nuclear magnetic resonance studies, and that yielded a new monoclonal antibody-defined epitope. The presence of zinc and metallothionein has been demonstrated within TEC which produce the peptide, suggesting that the molecule is secreted in its active zinc-containing form. The zinc/thymulin relationship, was further studied using various models of mild zinc deficiency in experimental animals and in humans. Serum thymulin activity was decreased as a result of zinc deficiency, and was corrected by in vivo and in vitro zinc supplementation, suggesting that this parameter could be a sensitive indicator of zinc deficiency. When considered together with the parallel variations seen in T-cell subpopulations and lymphokine production, these observations could provide a possible explanation of the role of zinc on T cell functions. |
format | Text |
id | pubmed-2364880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23648802008-05-12 Interactions Between Zinc and Thymulin Dardenne, Mireille Pleau, Jean-Marie Met Based Drugs Research Article Thymulin (formerly called "Facteur Thymique Sérique or FTS) is a metallopeptidic hormone selectively produced by thymic epithelial cells (TEC) and known to induce intra and extra-thymic T cell differentiation. It was initially isolated from porcine serum and shown to be present in calf thymus extract. Its amino-acid sequence was determined (<Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn). It is a nonapeptide whose biological activity is dependent on the presence of zinc, in an equimolecular ratio. The metallopeptide thus formed bears a specific tridimensional conformation detected by nuclear magnetic resonance studies, and that yielded a new monoclonal antibody-defined epitope. The presence of zinc and metallothionein has been demonstrated within TEC which produce the peptide, suggesting that the molecule is secreted in its active zinc-containing form. The zinc/thymulin relationship, was further studied using various models of mild zinc deficiency in experimental animals and in humans. Serum thymulin activity was decreased as a result of zinc deficiency, and was corrected by in vivo and in vitro zinc supplementation, suggesting that this parameter could be a sensitive indicator of zinc deficiency. When considered together with the parallel variations seen in T-cell subpopulations and lymphokine production, these observations could provide a possible explanation of the role of zinc on T cell functions. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364880/ /pubmed/18476235 http://dx.doi.org/10.1155/MBD.1994.233 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dardenne, Mireille Pleau, Jean-Marie Interactions Between Zinc and Thymulin |
title | Interactions Between Zinc and Thymulin |
title_full | Interactions Between Zinc and Thymulin |
title_fullStr | Interactions Between Zinc and Thymulin |
title_full_unstemmed | Interactions Between Zinc and Thymulin |
title_short | Interactions Between Zinc and Thymulin |
title_sort | interactions between zinc and thymulin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364880/ https://www.ncbi.nlm.nih.gov/pubmed/18476235 http://dx.doi.org/10.1155/MBD.1994.233 |
work_keys_str_mv | AT dardennemireille interactionsbetweenzincandthymulin AT pleaujeanmarie interactionsbetweenzincandthymulin |