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In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases
A series of phosphinegold(I) thionucleobase analogues, [R(3)PAu(SR(x))] (R = Et, Ph or chexyl; HSR(1) = 2-mercaptobenzoic acid, HSR(2) = 2-thiouracil, HSR(3) = 6-mercaptopurine and HSR(4) = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. T...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
1994
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364903/ https://www.ncbi.nlm.nih.gov/pubmed/18476243 http://dx.doi.org/10.1155/MBD.1994.299 |
| _version_ | 1782154038864773120 |
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| author | Tiekink, Edward R. T. Cookson, Peter D. Linahan, Bernadette M. Webster, Lorraine K. |
| author_facet | Tiekink, Edward R. T. Cookson, Peter D. Linahan, Bernadette M. Webster, Lorraine K. |
| author_sort | Tiekink, Edward R. T. |
| collection | PubMed |
| description | A series of phosphinegold(I) thionucleobase analogues, [R(3)PAu(SR(x))] (R = Et, Ph or chexyl; HSR(1) = 2-mercaptobenzoic acid, HSR(2) = 2-thiouracil, HSR(3) = 6-mercaptopurine and HSR(4) = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID(50) values (continuous 48 h exposure) for the complexes is 0.041 - 0.131 μM. The complexes with SR(3) and SR(3) are generally the most active; however, there is no clear trend associated with the phosphine ligands. |
| format | Text |
| id | pubmed-2364903 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1994 |
| publisher | Hindawi Publishing Corporation |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-23649032008-05-12 In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases Tiekink, Edward R. T. Cookson, Peter D. Linahan, Bernadette M. Webster, Lorraine K. Met Based Drugs Research Article A series of phosphinegold(I) thionucleobase analogues, [R(3)PAu(SR(x))] (R = Et, Ph or chexyl; HSR(1) = 2-mercaptobenzoic acid, HSR(2) = 2-thiouracil, HSR(3) = 6-mercaptopurine and HSR(4) = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID(50) values (continuous 48 h exposure) for the complexes is 0.041 - 0.131 μM. The complexes with SR(3) and SR(3) are generally the most active; however, there is no clear trend associated with the phosphine ligands. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364903/ /pubmed/18476243 http://dx.doi.org/10.1155/MBD.1994.299 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Tiekink, Edward R. T. Cookson, Peter D. Linahan, Bernadette M. Webster, Lorraine K. In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases |
| title |
In Vitro Antitumour Activity of Some Triorganophosphinegold(I)
Thionucleobases |
| title_full |
In Vitro Antitumour Activity of Some Triorganophosphinegold(I)
Thionucleobases |
| title_fullStr |
In Vitro Antitumour Activity of Some Triorganophosphinegold(I)
Thionucleobases |
| title_full_unstemmed |
In Vitro Antitumour Activity of Some Triorganophosphinegold(I)
Thionucleobases |
| title_short |
In Vitro Antitumour Activity of Some Triorganophosphinegold(I)
Thionucleobases |
| title_sort | in vitro antitumour activity of some triorganophosphinegold(i)
thionucleobases |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364903/ https://www.ncbi.nlm.nih.gov/pubmed/18476243 http://dx.doi.org/10.1155/MBD.1994.299 |
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