Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives

Two diphenylantimony(III) derivatives of dithiophosphorus ligands, i.e. Ph(2)SbS(2)PPh(2) and Ph(2)SbS(2)P(OPr-i)(2), which were previously found to exhibit antitumor properties, have been now investigated for potential mutagenic effects in healthy and Ehrlich ascites tumor-bearing mice. Two short-t...

Descripción completa

Detalles Bibliográficos
Autores principales: Socaciu, Carmen, Pasca, Ioan, Silvestru, Cristian, Bara, Adela, Haiduc, Ionel
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364908/
https://www.ncbi.nlm.nih.gov/pubmed/18476242
http://dx.doi.org/10.1155/MBD.1994.291a
_version_ 1782154040043372544
author Socaciu, Carmen
Pasca, Ioan
Silvestru, Cristian
Bara, Adela
Haiduc, Ionel
author_facet Socaciu, Carmen
Pasca, Ioan
Silvestru, Cristian
Bara, Adela
Haiduc, Ionel
author_sort Socaciu, Carmen
collection PubMed
description Two diphenylantimony(III) derivatives of dithiophosphorus ligands, i.e. Ph(2)SbS(2)PPh(2) and Ph(2)SbS(2)P(OPr-i)(2), which were previously found to exhibit antitumor properties, have been now investigated for potential mutagenic effects in healthy and Ehrlich ascites tumor-bearing mice. Two short-term tests, i.e. the micronucleus test and the cytogenetic analysis, were used as end-points for mutagenicity. The results are consistent with a mutagenic potential for both organoantimony(III) compounds tested, the effect being higher for the phosphorodithioato derivative.
format Text
id pubmed-2364908
institution National Center for Biotechnology Information
language English
publishDate 1994
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-23649082008-05-12 Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives Socaciu, Carmen Pasca, Ioan Silvestru, Cristian Bara, Adela Haiduc, Ionel Met Based Drugs Research Article Two diphenylantimony(III) derivatives of dithiophosphorus ligands, i.e. Ph(2)SbS(2)PPh(2) and Ph(2)SbS(2)P(OPr-i)(2), which were previously found to exhibit antitumor properties, have been now investigated for potential mutagenic effects in healthy and Ehrlich ascites tumor-bearing mice. Two short-term tests, i.e. the micronucleus test and the cytogenetic analysis, were used as end-points for mutagenicity. The results are consistent with a mutagenic potential for both organoantimony(III) compounds tested, the effect being higher for the phosphorodithioato derivative. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364908/ /pubmed/18476242 http://dx.doi.org/10.1155/MBD.1994.291a Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Socaciu, Carmen
Pasca, Ioan
Silvestru, Cristian
Bara, Adela
Haiduc, Ionel
Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives
title Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives
title_full Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives
title_fullStr Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives
title_full_unstemmed Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives
title_short Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives
title_sort antitumor organometallics. iv. the mutagenic potential of some diphenylantimony(iii) dithiophosphorus derivatives
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364908/
https://www.ncbi.nlm.nih.gov/pubmed/18476242
http://dx.doi.org/10.1155/MBD.1994.291a
work_keys_str_mv AT socaciucarmen antitumororganometallicsivthemutagenicpotentialofsomediphenylantimonyiiidithiophosphorusderivatives
AT pascaioan antitumororganometallicsivthemutagenicpotentialofsomediphenylantimonyiiidithiophosphorusderivatives
AT silvestrucristian antitumororganometallicsivthemutagenicpotentialofsomediphenylantimonyiiidithiophosphorusderivatives
AT baraadela antitumororganometallicsivthemutagenicpotentialofsomediphenylantimonyiiidithiophosphorusderivatives
AT haiducionel antitumororganometallicsivthemutagenicpotentialofsomediphenylantimonyiiidithiophosphorusderivatives

Ejemplares similares