Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links

The stereochemical factors that influence the tendencies for sequence specific binding of platinum antitumour drugs to DNA are examined. The NHs of the platinum-amine moiety can form hydrogen bonds to the O6 of guanine or to a phosphate oxygen of DNA. Modelling the stereochemistry of the NH atoms ca...

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Detalles Bibliográficos
Autor principal: Natile, Giovanni
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364910/
https://www.ncbi.nlm.nih.gov/pubmed/18476245
http://dx.doi.org/10.1155/MBD.1994.311
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author Natile, Giovanni
author_facet Natile, Giovanni
author_sort Natile, Giovanni
collection PubMed
description The stereochemical factors that influence the tendencies for sequence specific binding of platinum antitumour drugs to DNA are examined. The NHs of the platinum-amine moiety can form hydrogen bonds to the O6 of guanine or to a phosphate oxygen of DNA. Modelling the stereochemistry of the NH atoms can lead to compounds with a strong preference for forming one type of adduct with DNA.
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spelling pubmed-23649102008-05-12 Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links Natile, Giovanni Met Based Drugs Research Article The stereochemical factors that influence the tendencies for sequence specific binding of platinum antitumour drugs to DNA are examined. The NHs of the platinum-amine moiety can form hydrogen bonds to the O6 of guanine or to a phosphate oxygen of DNA. Modelling the stereochemistry of the NH atoms can lead to compounds with a strong preference for forming one type of adduct with DNA. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364910/ /pubmed/18476245 http://dx.doi.org/10.1155/MBD.1994.311 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Natile, Giovanni
Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
title Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
title_full Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
title_fullStr Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
title_full_unstemmed Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
title_short Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
title_sort contribution of h-bonding to the preference of platinum anti-tumour drugs for particular bases and particular cross-links
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364910/
https://www.ncbi.nlm.nih.gov/pubmed/18476245
http://dx.doi.org/10.1155/MBD.1994.311
work_keys_str_mv AT natilegiovanni contributionofhbondingtothepreferenceofplatinumantitumourdrugsforparticularbasesandparticularcrosslinks

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