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Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links
The stereochemical factors that influence the tendencies for sequence specific binding of platinum antitumour drugs to DNA are examined. The NHs of the platinum-amine moiety can form hydrogen bonds to the O6 of guanine or to a phosphate oxygen of DNA. Modelling the stereochemistry of the NH atoms ca...
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| Formato: | Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
1994
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364910/ https://www.ncbi.nlm.nih.gov/pubmed/18476245 http://dx.doi.org/10.1155/MBD.1994.311 |