Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane

The synthesis and crystal and molecular structures of the platinum(II) complex Pt(HL)Cl where H(2)L is the diacid diamide –[CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), a hydrolytic metabolite of an antitumour active bis(3,5-dioxopiperazin-1-yl)alkane are reported. The complex is square planar and contains HL...

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Autores principales: Nolan, Kevin B., Ryan, Leo P., Campbell, Colm J., McArdle, Patrick, Cunningham, Desmond, Higgins, Tim
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364911/
https://www.ncbi.nlm.nih.gov/pubmed/18476246
http://dx.doi.org/10.1155/MBD.1994.321
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author Nolan, Kevin B.
Ryan, Leo P.
Campbell, Colm J.
McArdle, Patrick
Cunningham, Desmond
Higgins, Tim
author_facet Nolan, Kevin B.
Ryan, Leo P.
Campbell, Colm J.
McArdle, Patrick
Cunningham, Desmond
Higgins, Tim
author_sort Nolan, Kevin B.
collection PubMed
description The synthesis and crystal and molecular structures of the platinum(II) complex Pt(HL)Cl where H(2)L is the diacid diamide –[CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), a hydrolytic metabolite of an antitumour active bis(3,5-dioxopiperazin-1-yl)alkane are reported. The complex is square planar and contains HL(–) as a tridentate 2N (amino), O (carboxylate) donor. The metal to ligand bond distances are Pt-Cl 2.287(1) Å, Pt-O 2.002 (1) Å, Pt-N(trans Cl) 2.014(1) Å and Pt-N(trans O) 2.073 Å. There is extensive hydrogen bonding, each molecule of Pt(HL)Cl being intermolecularly hydrogen bonded to ten others giving a 3-dimensional network. There is also one intramolecular H-bond.
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spelling pubmed-23649112008-05-12 Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane Nolan, Kevin B. Ryan, Leo P. Campbell, Colm J. McArdle, Patrick Cunningham, Desmond Higgins, Tim Met Based Drugs Research Article The synthesis and crystal and molecular structures of the platinum(II) complex Pt(HL)Cl where H(2)L is the diacid diamide –[CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), a hydrolytic metabolite of an antitumour active bis(3,5-dioxopiperazin-1-yl)alkane are reported. The complex is square planar and contains HL(–) as a tridentate 2N (amino), O (carboxylate) donor. The metal to ligand bond distances are Pt-Cl 2.287(1) Å, Pt-O 2.002 (1) Å, Pt-N(trans Cl) 2.014(1) Å and Pt-N(trans O) 2.073 Å. There is extensive hydrogen bonding, each molecule of Pt(HL)Cl being intermolecularly hydrogen bonded to ten others giving a 3-dimensional network. There is also one intramolecular H-bond. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364911/ /pubmed/18476246 http://dx.doi.org/10.1155/MBD.1994.321 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nolan, Kevin B.
Ryan, Leo P.
Campbell, Colm J.
McArdle, Patrick
Cunningham, Desmond
Higgins, Tim
Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane
title Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane
title_full Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane
title_fullStr Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane
title_full_unstemmed Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane
title_short Preparation and Crystal Structure of a Platinum(II) Complex of [CH(2)N(CH(2)COOH)CH(2)CONH(2)](2), the Hydrolysis Product of an Anti-Tumour Bis(3,5-Dioxopiperazin-1-YL)Alkane
title_sort preparation and crystal structure of a platinum(ii) complex of [ch(2)n(ch(2)cooh)ch(2)conh(2)](2), the hydrolysis product of an anti-tumour bis(3,5-dioxopiperazin-1-yl)alkane
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364911/
https://www.ncbi.nlm.nih.gov/pubmed/18476246
http://dx.doi.org/10.1155/MBD.1994.321
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