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Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands
A series of new ethylenediamine (en) platinum(IV) complexes of the type Pt((IV))enX(2)A(2), with X(2) = cyclobutane-1,1-dicarboxylato (CBDCA), dichloro or bis(decanoato) and A = acetato, dodecanoato, tetradecanoato, hexadecanoato, octadecanoato, adamantanecarboxylato (Ad) or 3α, 12α-diformoxy-5β-ch...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1995
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364949/ https://www.ncbi.nlm.nih.gov/pubmed/18472746 http://dx.doi.org/10.1155/MBD.1995.57 |
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author | Galanski, M. Keppler, B. K. |
author_facet | Galanski, M. Keppler, B. K. |
author_sort | Galanski, M. |
collection | PubMed |
description | A series of new ethylenediamine (en) platinum(IV) complexes of the type Pt((IV))enX(2)A(2), with X(2) = cyclobutane-1,1-dicarboxylato (CBDCA), dichloro or bis(decanoato) and A = acetato, dodecanoato, tetradecanoato, hexadecanoato, octadecanoato, adamantanecarboxylato (Ad) or 3α, 12α-diformoxy-5β-cholato (DFCA) were synthesized and characterized by elemental analysis, infrared and NMR ((1)H and (13)C) spectroscopic techniques. Previous platinum(IV) compounds were usually restricted to trans-dihydroxo or trans-dichloro platinum(IV) complexes. Recently trans-dicarboxylato platinum(IV) complexes with mainly acetate, trifluoracetate or short-chain carboxylate groups (<11 carbons) in the axial position have been described in the literature([1,2,3]). In this paper we report on the synthesis and characterization of a new class of ethylenediamine platinum(IV) compounds that have high lipophilic long-chain carboxylate ligands either in the axial or equatorial position. The platinum(IV) compounds with the lipophilic trans-carboxylate ligands in the axial position were prepared by acylation of the trans-dihydroxo platinum(IV) species using an acyl halide in the presence of pyridine. In contrast to previous publications([1]) the yields were excellent (up to 94%!). |
format | Text |
id | pubmed-2364949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23649492008-05-12 Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands Galanski, M. Keppler, B. K. Met Based Drugs Research Article A series of new ethylenediamine (en) platinum(IV) complexes of the type Pt((IV))enX(2)A(2), with X(2) = cyclobutane-1,1-dicarboxylato (CBDCA), dichloro or bis(decanoato) and A = acetato, dodecanoato, tetradecanoato, hexadecanoato, octadecanoato, adamantanecarboxylato (Ad) or 3α, 12α-diformoxy-5β-cholato (DFCA) were synthesized and characterized by elemental analysis, infrared and NMR ((1)H and (13)C) spectroscopic techniques. Previous platinum(IV) compounds were usually restricted to trans-dihydroxo or trans-dichloro platinum(IV) complexes. Recently trans-dicarboxylato platinum(IV) complexes with mainly acetate, trifluoracetate or short-chain carboxylate groups (<11 carbons) in the axial position have been described in the literature([1,2,3]). In this paper we report on the synthesis and characterization of a new class of ethylenediamine platinum(IV) compounds that have high lipophilic long-chain carboxylate ligands either in the axial or equatorial position. The platinum(IV) compounds with the lipophilic trans-carboxylate ligands in the axial position were prepared by acylation of the trans-dihydroxo platinum(IV) species using an acyl halide in the presence of pyridine. In contrast to previous publications([1]) the yields were excellent (up to 94%!). Hindawi Publishing Corporation 1995 /pmc/articles/PMC2364949/ /pubmed/18472746 http://dx.doi.org/10.1155/MBD.1995.57 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Galanski, M. Keppler, B. K. Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands |
title | Synthesis and Characterization
of New Ethylenediamine Platinum(IV) Complexes Containing
Lipophilic Carboxylate Ligands |
title_full | Synthesis and Characterization
of New Ethylenediamine Platinum(IV) Complexes Containing
Lipophilic Carboxylate Ligands |
title_fullStr | Synthesis and Characterization
of New Ethylenediamine Platinum(IV) Complexes Containing
Lipophilic Carboxylate Ligands |
title_full_unstemmed | Synthesis and Characterization
of New Ethylenediamine Platinum(IV) Complexes Containing
Lipophilic Carboxylate Ligands |
title_short | Synthesis and Characterization
of New Ethylenediamine Platinum(IV) Complexes Containing
Lipophilic Carboxylate Ligands |
title_sort | synthesis and characterization
of new ethylenediamine platinum(iv) complexes containing
lipophilic carboxylate ligands |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364949/ https://www.ncbi.nlm.nih.gov/pubmed/18472746 http://dx.doi.org/10.1155/MBD.1995.57 |
work_keys_str_mv | AT galanskim synthesisandcharacterizationofnewethylenediamineplatinumivcomplexescontaininglipophiliccarboxylateligands AT kepplerbk synthesisandcharacterizationofnewethylenediamineplatinumivcomplexescontaininglipophiliccarboxylateligands |