Cargando…
UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA
cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced re...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1995
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364964/ https://www.ncbi.nlm.nih.gov/pubmed/18472759 http://dx.doi.org/10.1155/MBD.1995.137 |
_version_ | 1782154053406425088 |
---|---|
author | Payet, Dominique Leng, Marc |
author_facet | Payet, Dominique Leng, Marc |
author_sort | Payet, Dominique |
collection | PubMed |
description | cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated. |
format | Text |
id | pubmed-2364964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23649642008-05-12 UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA Payet, Dominique Leng, Marc Met Based Drugs Research Article cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated. Hindawi Publishing Corporation 1995 /pmc/articles/PMC2364964/ /pubmed/18472759 http://dx.doi.org/10.1155/MBD.1995.137 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Payet, Dominique Leng, Marc UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA |
title | UVA-Photosensitivity
of cis-Diamminedichloro-Platinum(II)-Modified DNA
|
title_full | UVA-Photosensitivity
of cis-Diamminedichloro-Platinum(II)-Modified DNA
|
title_fullStr | UVA-Photosensitivity
of cis-Diamminedichloro-Platinum(II)-Modified DNA
|
title_full_unstemmed | UVA-Photosensitivity
of cis-Diamminedichloro-Platinum(II)-Modified DNA
|
title_short | UVA-Photosensitivity
of cis-Diamminedichloro-Platinum(II)-Modified DNA
|
title_sort | uva-photosensitivity
of cis-diamminedichloro-platinum(ii)-modified dna |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364964/ https://www.ncbi.nlm.nih.gov/pubmed/18472759 http://dx.doi.org/10.1155/MBD.1995.137 |
work_keys_str_mv | AT payetdominique uvaphotosensitivityofcisdiamminedichloroplatinumiimodifieddna AT lengmarc uvaphotosensitivityofcisdiamminedichloroplatinumiimodifieddna |