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UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA

cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced re...

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Detalles Bibliográficos
Autores principales: Payet, Dominique, Leng, Marc
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364964/
https://www.ncbi.nlm.nih.gov/pubmed/18472759
http://dx.doi.org/10.1155/MBD.1995.137
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author Payet, Dominique
Leng, Marc
author_facet Payet, Dominique
Leng, Marc
author_sort Payet, Dominique
collection PubMed
description cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated.
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spelling pubmed-23649642008-05-12 UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA Payet, Dominique Leng, Marc Met Based Drugs Research Article cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated. Hindawi Publishing Corporation 1995 /pmc/articles/PMC2364964/ /pubmed/18472759 http://dx.doi.org/10.1155/MBD.1995.137 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Payet, Dominique
Leng, Marc
UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA
title UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA
title_full UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA
title_fullStr UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA
title_full_unstemmed UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA
title_short UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA
title_sort uva-photosensitivity of cis-diamminedichloro-platinum(ii)-modified dna
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364964/
https://www.ncbi.nlm.nih.gov/pubmed/18472759
http://dx.doi.org/10.1155/MBD.1995.137
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