Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound

A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with t...

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Detalles Bibliográficos
Autores principales: Vilaplana, R., Romero, M. A., Quirós, M., Salas, J. M., González-Vílchez, F.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364974/
https://www.ncbi.nlm.nih.gov/pubmed/18472768
http://dx.doi.org/10.1155/MBD.1995.211
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author Vilaplana, R.
Romero, M. A.
Quirós, M.
Salas, J. M.
González-Vílchez, F.
author_facet Vilaplana, R.
Romero, M. A.
Quirós, M.
Salas, J. M.
González-Vílchez, F.
author_sort Vilaplana, R.
collection PubMed
description A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with two chlorine atoms in a cis conformation. The antitumour activity against a variety of murine and human cancers is reported.
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spelling pubmed-23649742008-05-12 Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound Vilaplana, R. Romero, M. A. Quirós, M. Salas, J. M. González-Vílchez, F. Met Based Drugs Research Article A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with two chlorine atoms in a cis conformation. The antitumour activity against a variety of murine and human cancers is reported. Hindawi Publishing Corporation 1995 /pmc/articles/PMC2364974/ /pubmed/18472768 http://dx.doi.org/10.1155/MBD.1995.211 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vilaplana, R.
Romero, M. A.
Quirós, M.
Salas, J. M.
González-Vílchez, F.
Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound
title Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound
title_full Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound
title_fullStr Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound
title_full_unstemmed Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound
title_short Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound
title_sort synthesis, structure and antitumour properties of a new 1,2-propylenediaminetetraacetate-ruthenium(iii) compound
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364974/
https://www.ncbi.nlm.nih.gov/pubmed/18472768
http://dx.doi.org/10.1155/MBD.1995.211
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