Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors

Co(II); Zn(II) and Cu(II) complexes of two new sulfonamide carbonic anhydrase (CA) inhibitors, derivatives of thienothiopyran-2-sulfonamide, were prepared and characterized by analytic, spectroscopic, magnetic and conductimetric measurements. The new complexes are more potent CA inhibitors than the...

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Detalles Bibliográficos
Autor principal: Supuran, Claudiu T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364991/
https://www.ncbi.nlm.nih.gov/pubmed/18472783
http://dx.doi.org/10.1155/MBD.1995.327
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author Supuran, Claudiu T.
author_facet Supuran, Claudiu T.
author_sort Supuran, Claudiu T.
collection PubMed
description Co(II); Zn(II) and Cu(II) complexes of two new sulfonamide carbonic anhydrase (CA) inhibitors, derivatives of thienothiopyran-2-sulfonamide, were prepared and characterized by analytic, spectroscopic, magnetic and conductimetric measurements. The new complexes are more potent CA inhibitors than the parent sulfonamides, with IC(50) values around 0.1 nM, against isozyme CA II.
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spelling pubmed-23649912008-05-12 Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors Supuran, Claudiu T. Met Based Drugs Research Article Co(II); Zn(II) and Cu(II) complexes of two new sulfonamide carbonic anhydrase (CA) inhibitors, derivatives of thienothiopyran-2-sulfonamide, were prepared and characterized by analytic, spectroscopic, magnetic and conductimetric measurements. The new complexes are more potent CA inhibitors than the parent sulfonamides, with IC(50) values around 0.1 nM, against isozyme CA II. Hindawi Publishing Corporation 1995 /pmc/articles/PMC2364991/ /pubmed/18472783 http://dx.doi.org/10.1155/MBD.1995.327 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Supuran, Claudiu T.
Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors
title Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors
title_full Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors
title_fullStr Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors
title_full_unstemmed Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors
title_short Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors
title_sort thienothiopyransulfonamides as complexing agents for the preparation of dual carbonic anhydrase inhibitors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364991/
https://www.ncbi.nlm.nih.gov/pubmed/18472783
http://dx.doi.org/10.1155/MBD.1995.327
work_keys_str_mv AT supuranclaudiut thienothiopyransulfonamidesascomplexingagentsforthepreparationofdualcarbonicanhydraseinhibitors

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