Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations

Complexes of diazoxide (3-methyl-7-chloro-1,2,4-benzothiadiazine-1,1-dioxide) - an antihypertensive and hyperglycemic pharmacological agent - with a series of transition- and main-group di-, triand tetravalent metal ions were prepared and characterized by elemental analysis, spectroscopic, thermogra...

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Detalles Bibliográficos
Autor principal: Supuran, Claudiu T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364994/
https://www.ncbi.nlm.nih.gov/pubmed/18472790
http://dx.doi.org/10.1155/MBD.1996.25
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author Supuran, Claudiu T.
author_facet Supuran, Claudiu T.
author_sort Supuran, Claudiu T.
collection PubMed
description Complexes of diazoxide (3-methyl-7-chloro-1,2,4-benzothiadiazine-1,1-dioxide) - an antihypertensive and hyperglycemic pharmacological agent - with a series of transition- and main-group di-, triand tetravalent metal ions were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes were tested as inhibitors of the enzyme carbonic anhydrase (CA), proving modest activity towards CA II and better inhibition of CA I.
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spelling pubmed-23649942008-05-12 Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations Supuran, Claudiu T. Met Based Drugs Research Article Complexes of diazoxide (3-methyl-7-chloro-1,2,4-benzothiadiazine-1,1-dioxide) - an antihypertensive and hyperglycemic pharmacological agent - with a series of transition- and main-group di-, triand tetravalent metal ions were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes were tested as inhibitors of the enzyme carbonic anhydrase (CA), proving modest activity towards CA II and better inhibition of CA I. Hindawi Publishing Corporation 1996 /pmc/articles/PMC2364994/ /pubmed/18472790 http://dx.doi.org/10.1155/MBD.1996.25 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Supuran, Claudiu T.
Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations
title Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations
title_full Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations
title_fullStr Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations
title_full_unstemmed Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations
title_short Complexes With Biologically Active Ligands. Part 1. Synthesis of Coordination Compounds of Diazoxide With Transition- and Main-Group Cations
title_sort complexes with biologically active ligands. part 1. synthesis of coordination compounds of diazoxide with transition- and main-group cations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364994/
https://www.ncbi.nlm.nih.gov/pubmed/18472790
http://dx.doi.org/10.1155/MBD.1996.25
work_keys_str_mv AT supuranclaudiut complexeswithbiologicallyactiveligandspart1synthesisofcoordinationcompoundsofdiazoxidewithtransitionandmaingroupcations

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