Complexes of Zinc With Picolinic and Aspartic Acids Inactivate Free Varicella-Zoster Virions

Zn(II) picolinate and aspartate, Zn(pic)(2) and Zn(asp)(2), have been shown to inhibit key steps of the replication of HSV-1. In the present study we describe the effect of Zn(pic)(2) and Zn(asp)(2) on the replication of VZV and on the infectivity of free virions. The experiments are done using BHK-...

Descripción completa

Detalles Bibliográficos
Autores principales: Shishkov, S., Varadinova, T., Bontchev, P., Nachev, C., Michailova, E.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364995/
https://www.ncbi.nlm.nih.gov/pubmed/18472788
http://dx.doi.org/10.1155/MBD.1996.11
Descripción
Sumario:Zn(II) picolinate and aspartate, Zn(pic)(2) and Zn(asp)(2), have been shown to inhibit key steps of the replication of HSV-1. In the present study we describe the effect of Zn(pic)(2) and Zn(asp)(2) on the replication of VZV and on the infectivity of free virions. The experiments are done using BHK-21 cells, a clinical isolate of VZV and Zn-complexes in concentration of 10 μM. When Zn-complexes are present during the whole period of infection, the yield of infectious virus progeny decreases up to 98%. The infectivity of VZV is completely restored after the removal of zinc. The virucidal effect is manifested at the 2nd h of contact, when 90% of the virions are inactivated. The results show that both Zn(pic)(2) and Zn(asp)(2) specifically inactivate free VZV virions with no effect on viral replication.

Ejemplares similares