Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity

The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distort...

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Autores principales: Gielen, Marcel, Bouhdid, Abdeslam, Tiekink, Edward R. T., de Vos, Dick, Willem, Rudolph
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365004/
https://www.ncbi.nlm.nih.gov/pubmed/18472799
http://dx.doi.org/10.1155/MBD.1996.75
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author Gielen, Marcel
Bouhdid, Abdeslam
Tiekink, Edward R. T.
de Vos, Dick
Willem, Rudolph
author_facet Gielen, Marcel
Bouhdid, Abdeslam
Tiekink, Edward R. T.
de Vos, Dick
Willem, Rudolph
author_sort Gielen, Marcel
collection PubMed
description The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distorted tetrahedral geometry because of monodentate coordination, as a thiolate (Sn-S 2.431(2) Å), of the ortho-aminophenylthiolate ligand. The in vitro antitumour activities of 1 and 2, against a number of cell lines, are comparable to those exhibited by methotrexate and doxorubicin, and higher than those of carboplatin and cisplatin.
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spelling pubmed-23650042008-05-12 Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity Gielen, Marcel Bouhdid, Abdeslam Tiekink, Edward R. T. de Vos, Dick Willem, Rudolph Met Based Drugs Research Article The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distorted tetrahedral geometry because of monodentate coordination, as a thiolate (Sn-S 2.431(2) Å), of the ortho-aminophenylthiolate ligand. The in vitro antitumour activities of 1 and 2, against a number of cell lines, are comparable to those exhibited by methotrexate and doxorubicin, and higher than those of carboplatin and cisplatin. Hindawi Publishing Corporation 1996 /pmc/articles/PMC2365004/ /pubmed/18472799 http://dx.doi.org/10.1155/MBD.1996.75 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gielen, Marcel
Bouhdid, Abdeslam
Tiekink, Edward R. T.
de Vos, Dick
Willem, Rudolph
Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity
title Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity
title_full Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity
title_fullStr Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity
title_full_unstemmed Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity
title_short Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity
title_sort triphenyltin ortho-aminophenyl- and 2-pyridyl-thiolates: synthesis and in vitro antitumour activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365004/
https://www.ncbi.nlm.nih.gov/pubmed/18472799
http://dx.doi.org/10.1155/MBD.1996.75
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