Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases

The [Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcin...

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Detalles Bibliográficos
Autores principales: Webster, Lorraine K., Rainone, Silvina, Horn, Ernst, Tiekink, Edward R. T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365007/
https://www.ncbi.nlm.nih.gov/pubmed/18472797
http://dx.doi.org/10.1155/MBD.1996.63
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author Webster, Lorraine K.
Rainone, Silvina
Horn, Ernst
Tiekink, Edward R. T.
author_facet Webster, Lorraine K.
Rainone, Silvina
Horn, Ernst
Tiekink, Edward R. T.
author_sort Webster, Lorraine K.
collection PubMed
description The [Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph(3)PAu(6-MP)] and [Ph(3)PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [Ph(3)PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin.
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spelling pubmed-23650072008-05-12 Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases Webster, Lorraine K. Rainone, Silvina Horn, Ernst Tiekink, Edward R. T. Met Based Drugs Research Article The [Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph(3)PAu(6-MP)] and [Ph(3)PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [Ph(3)PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin. Hindawi Publishing Corporation 1996 /pmc/articles/PMC2365007/ /pubmed/18472797 http://dx.doi.org/10.1155/MBD.1996.63 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Webster, Lorraine K.
Rainone, Silvina
Horn, Ernst
Tiekink, Edward R. T.
Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
title Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
title_full Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
title_fullStr Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
title_full_unstemmed Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
title_short Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
title_sort anti-tumor activity, in vitro and in vivo, of some triphenylphosphinegold(i) thionucleobases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365007/
https://www.ncbi.nlm.nih.gov/pubmed/18472797
http://dx.doi.org/10.1155/MBD.1996.63
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