New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential

Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated. The new complexes are: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were char...

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Detalles Bibliográficos
Autores principales: de Oliveira, M. B., Miller, J., Banks, R. E., Kelland, L. R., McAuliffe, C. A., Mahmood, N., Rowland, I. J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365017/
https://www.ncbi.nlm.nih.gov/pubmed/18472806
http://dx.doi.org/10.1155/MBD.1996.117
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author de Oliveira, M. B.
Miller, J.
Banks, R. E.
Kelland, L. R.
McAuliffe, C. A.
Mahmood, N.
Rowland, I. J.
author_facet de Oliveira, M. B.
Miller, J.
Banks, R. E.
Kelland, L. R.
McAuliffe, C. A.
Mahmood, N.
Rowland, I. J.
author_sort de Oliveira, M. B.
collection PubMed
description Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated. The new complexes are: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were characterized by elemental analysis, IR spectra and (1)H and (13)C NMR spectra. They were tested against five human ovarian carcinoma cell lines, viz., CH1, CH1cisR, A2780, A2780cisR and SKOV-3. They were less active than cis-platin and showed cross-resistance with cis-platin in the CH1cisR and A2780cisR acquired resistance lines. They were also tested for possible anti-HIV activity using the HIV-I IIIB virus and C8166 cells, but they were inactive compared with AZT.
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spelling pubmed-23650172008-05-12 New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential de Oliveira, M. B. Miller, J. Banks, R. E. Kelland, L. R. McAuliffe, C. A. Mahmood, N. Rowland, I. J. Met Based Drugs Research Article Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated. The new complexes are: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were characterized by elemental analysis, IR spectra and (1)H and (13)C NMR spectra. They were tested against five human ovarian carcinoma cell lines, viz., CH1, CH1cisR, A2780, A2780cisR and SKOV-3. They were less active than cis-platin and showed cross-resistance with cis-platin in the CH1cisR and A2780cisR acquired resistance lines. They were also tested for possible anti-HIV activity using the HIV-I IIIB virus and C8166 cells, but they were inactive compared with AZT. Hindawi Publishing Corporation 1996 /pmc/articles/PMC2365017/ /pubmed/18472806 http://dx.doi.org/10.1155/MBD.1996.117 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
de Oliveira, M. B.
Miller, J.
Banks, R. E.
Kelland, L. R.
McAuliffe, C. A.
Mahmood, N.
Rowland, I. J.
New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential
title New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential
title_full New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential
title_fullStr New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential
title_full_unstemmed New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential
title_short New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential
title_sort new perfluorophtalate complexes of platinum(ii) with chemotherapeutic potential
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365017/
https://www.ncbi.nlm.nih.gov/pubmed/18472806
http://dx.doi.org/10.1155/MBD.1996.117
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