The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats

The boronated nucleosides with varying bases and sugar moieties were shown to be potent hypolipidemic agents in rodents. The 3′– aminocynaoborane dideoxythymidine derivative caused reductions in serum cholesterol and triglyceride levels, tissue lipids, VLDL and LDL cholesterol levels while elevating...

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Detalles Bibliográficos
Autores principales: Burnham, Bruce S., Sood, Anup, Tomasz, Jeno, Powell, W. J., Spielvogel, Bernard F., Chen, S. Y., Hall, Iris H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365024/
https://www.ncbi.nlm.nih.gov/pubmed/18475753
http://dx.doi.org/10.1155/MBD.1996.173
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author Burnham, Bruce S.
Sood, Anup
Tomasz, Jeno
Powell, W. J.
Spielvogel, Bernard F.
Chen, S. Y.
Hall, Iris H.
author_facet Burnham, Bruce S.
Sood, Anup
Tomasz, Jeno
Powell, W. J.
Spielvogel, Bernard F.
Chen, S. Y.
Hall, Iris H.
author_sort Burnham, Bruce S.
collection PubMed
description The boronated nucleosides with varying bases and sugar moieties were shown to be potent hypolipidemic agents in rodents. The 3′– aminocynaoborane dideoxythymidine derivative caused reductions in serum cholesterol and triglyceride levels, tissue lipids, VLDL and LDL cholesterol levels while elevating HDL cholesterol levels in rodents. The agents suppressed rat hepatic acetyl CoA synthetase, HMG-CoA reductase, acyl-CoA cholesterol acyl transferase, phosphatidylate phosphohydrolase and lipoprotein lipase activities while elevating cholesterol-7α-hydroxylase activity from 25 to 100 μM.
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spelling pubmed-23650242008-05-12 The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats Burnham, Bruce S. Sood, Anup Tomasz, Jeno Powell, W. J. Spielvogel, Bernard F. Chen, S. Y. Hall, Iris H. Met Based Drugs Research Article The boronated nucleosides with varying bases and sugar moieties were shown to be potent hypolipidemic agents in rodents. The 3′– aminocynaoborane dideoxythymidine derivative caused reductions in serum cholesterol and triglyceride levels, tissue lipids, VLDL and LDL cholesterol levels while elevating HDL cholesterol levels in rodents. The agents suppressed rat hepatic acetyl CoA synthetase, HMG-CoA reductase, acyl-CoA cholesterol acyl transferase, phosphatidylate phosphohydrolase and lipoprotein lipase activities while elevating cholesterol-7α-hydroxylase activity from 25 to 100 μM. Hindawi Publishing Corporation 1996 /pmc/articles/PMC2365024/ /pubmed/18475753 http://dx.doi.org/10.1155/MBD.1996.173 Text en Copyright © 1996 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Burnham, Bruce S.
Sood, Anup
Tomasz, Jeno
Powell, W. J.
Spielvogel, Bernard F.
Chen, S. Y.
Hall, Iris H.
The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats
title The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats
title_full The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats
title_fullStr The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats
title_full_unstemmed The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats
title_short The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats
title_sort hypolipidemic activity of boronated nucleosides in male mice and rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365024/
https://www.ncbi.nlm.nih.gov/pubmed/18475753
http://dx.doi.org/10.1155/MBD.1996.173
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