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Effects of Hypoxia and Transferrin on Toxicity and DNA Binding of Ruthenium Antitumor Agents in Hela Cells

Nuclear DNA binding and inhibition of growth of HeLa cells in culture were determined after 24 h incubation with the ruthenium anticancer agents cis-[Cl(2)(NH(3))(4)Ru]Cl (CCR) and (ImH)trans-[(Im)(2)Cl(4)Ru] (ICR) as a function of [Ru], Po(2), and added transferrin. Consistent with the “activation-...

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Detalles Bibliográficos
Autores principales:	Frasca, D., Ciampa, J., Emerson, J., Umans, R. S., Clarke, M. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 1996
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365025/ https://www.ncbi.nlm.nih.gov/pubmed/18475755 http://dx.doi.org/10.1155/MBD.1996.197

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