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Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1997
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365034/ https://www.ncbi.nlm.nih.gov/pubmed/18475762 http://dx.doi.org/10.1155/MBD.1997.27 |
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author | Mincione, Giovanna Scozzafava, Andrea Supuran, Claudiu T. |
author_facet | Mincione, Giovanna Scozzafava, Andrea Supuran, Claudiu T. |
author_sort | Mincione, Giovanna |
collection | PubMed |
description | Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (elemental analysis, spectroscopic, magnetic, thermogravimetric and conductimetric measurements). The new derivatives showed good inhibitory activity against three isozymes of carbonic anhydrase (CA), i.e., CA I, II and IV. |
format | Text |
id | pubmed-2365034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23650342008-05-12 Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes Mincione, Giovanna Scozzafava, Andrea Supuran, Claudiu T. Met Based Drugs Research Article Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (elemental analysis, spectroscopic, magnetic, thermogravimetric and conductimetric measurements). The new derivatives showed good inhibitory activity against three isozymes of carbonic anhydrase (CA), i.e., CA I, II and IV. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2365034/ /pubmed/18475762 http://dx.doi.org/10.1155/MBD.1997.27 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mincione, Giovanna Scozzafava, Andrea Supuran, Claudiu T. Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes |
title | Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes |
title_full | Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes |
title_fullStr | Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes |
title_full_unstemmed | Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes |
title_short | Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes |
title_sort | carbonic anhydrase inhibitors. part 46(1) inhibition of carbonic anhydrase isozymes i, ii and iv with trifluoromethylsulfonamide derivatives and their zinc(ii) and copper(ii) complexes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365034/ https://www.ncbi.nlm.nih.gov/pubmed/18475762 http://dx.doi.org/10.1155/MBD.1997.27 |
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