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Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes

Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (...

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Detalles Bibliográficos
Autores principales: Mincione, Giovanna, Scozzafava, Andrea, Supuran, Claudiu T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365034/
https://www.ncbi.nlm.nih.gov/pubmed/18475762
http://dx.doi.org/10.1155/MBD.1997.27
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author Mincione, Giovanna
Scozzafava, Andrea
Supuran, Claudiu T.
author_facet Mincione, Giovanna
Scozzafava, Andrea
Supuran, Claudiu T.
author_sort Mincione, Giovanna
collection PubMed
description Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (elemental analysis, spectroscopic, magnetic, thermogravimetric and conductimetric measurements). The new derivatives showed good inhibitory activity against three isozymes of carbonic anhydrase (CA), i.e., CA I, II and IV.
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spelling pubmed-23650342008-05-12 Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes Mincione, Giovanna Scozzafava, Andrea Supuran, Claudiu T. Met Based Drugs Research Article Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (elemental analysis, spectroscopic, magnetic, thermogravimetric and conductimetric measurements). The new derivatives showed good inhibitory activity against three isozymes of carbonic anhydrase (CA), i.e., CA I, II and IV. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2365034/ /pubmed/18475762 http://dx.doi.org/10.1155/MBD.1997.27 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mincione, Giovanna
Scozzafava, Andrea
Supuran, Claudiu T.
Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
title Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
title_full Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
title_fullStr Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
title_full_unstemmed Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
title_short Carbonic Anhydrase Inhibitors. Part 46(1) Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes
title_sort carbonic anhydrase inhibitors. part 46(1) inhibition of carbonic anhydrase isozymes i, ii and iv with trifluoromethylsulfonamide derivatives and their zinc(ii) and copper(ii) complexes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365034/
https://www.ncbi.nlm.nih.gov/pubmed/18475762
http://dx.doi.org/10.1155/MBD.1997.27
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