Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide

The title compound was prepared by an improved variant of the literature procedure, and metal complexes containing its anion and the following metal ions: Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Cu(II), V(IV), Fe(III) and Ag(I) were synthesized and characterized by standard procedures (elemental ana...

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Detalles Bibliográficos
Autores principales: Scozzafava, Andrea, Supuran, Claudiu T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365037/
https://www.ncbi.nlm.nih.gov/pubmed/18475761
http://dx.doi.org/10.1155/MBD.1997.19
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author Scozzafava, Andrea
Supuran, Claudiu T.
author_facet Scozzafava, Andrea
Supuran, Claudiu T.
author_sort Scozzafava, Andrea
collection PubMed
description The title compound was prepared by an improved variant of the literature procedure, and metal complexes containing its anion and the following metal ions: Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Cu(II), V(IV), Fe(III) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, NMR and EPR spectroscopy; TG, magnetic and conductimetric measurements). The parent sulfonamide and its metal complexes are potent inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II, and they might possess applications as selective cerebrovasodilating agents.
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spelling pubmed-23650372008-05-12 Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide Scozzafava, Andrea Supuran, Claudiu T. Met Based Drugs Research Article The title compound was prepared by an improved variant of the literature procedure, and metal complexes containing its anion and the following metal ions: Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Cu(II), V(IV), Fe(III) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, NMR and EPR spectroscopy; TG, magnetic and conductimetric measurements). The parent sulfonamide and its metal complexes are potent inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II, and they might possess applications as selective cerebrovasodilating agents. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2365037/ /pubmed/18475761 http://dx.doi.org/10.1155/MBD.1997.19 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Scozzafava, Andrea
Supuran, Claudiu T.
Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide
title Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide
title_full Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide
title_fullStr Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide
title_full_unstemmed Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide
title_short Complexes With Biologically Active Ligands. Part 10(1) Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide
title_sort complexes with biologically active ligands. part 10(1) inhibition of carbonic anhydrase isozymes i and ii with metal complexes of imidazo[2,1−b ]-1,3,4-thiadiazole-2-sulfonamide
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365037/
https://www.ncbi.nlm.nih.gov/pubmed/18475761
http://dx.doi.org/10.1155/MBD.1997.19
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AT supuranclaudiut complexeswithbiologicallyactiveligandspart101inhibitionofcarbonicanhydraseisozymesiandiiwithmetalcomplexesofimidazo21b134thiadiazole2sulfonamide

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