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Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1)

Our previous results show that Zn(pic)(2) and Zn(asp)(2) inhibit key steps of the replication of HSV-1. Anti-HSV effect of complexes of Co(II) with aminoacids Lys and Ser was also found. In the present study we describe the effect of complexes of Zn(II), Co(II) and Cu(II) with D-aminosugars on the r...

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Detalles Bibliográficos
Autores principales: Shishkov, S., Varadinova, T., Panteva, M., Bontchev, P.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365038/
https://www.ncbi.nlm.nih.gov/pubmed/18475763
http://dx.doi.org/10.1155/MBD.1997.35
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author Shishkov, S.
Varadinova, T.
Panteva, M.
Bontchev, P.
author_facet Shishkov, S.
Varadinova, T.
Panteva, M.
Bontchev, P.
author_sort Shishkov, S.
collection PubMed
description Our previous results show that Zn(pic)(2) and Zn(asp)(2) inhibit key steps of the replication of HSV-1. Anti-HSV effect of complexes of Co(II) with aminoacids Lys and Ser was also found. In the present study we describe the effect of complexes of Zn(II), Co(II) and Cu(II) with D-aminosugars on the replication of HSV-1 and on the infectivity of free virions. The experiments were done using primary rabbit kidney cells (r.k.), diploid human embryonal fibroblasts (F) and Vero cells. No differences in the toxicity of metal complexes on diploid cells- r.k. and F, were found. Neither metal complexes, nor ligands-galactosoxime and glucosoxime, influenced the viral replication. During 1-4h prolonged contact only Cu(Gl.NOH)(2) inactivated HSV-1 virions up to 90%. The results show that D-aminosugars are not suitable ligands for Zn(II), Cu(II) and Co(II) in respect of the inhibition of viral replication. However, only Cu(Gl.NOH)(2) was able to inhibit the infectivity of free virions.
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spelling pubmed-23650382008-05-12 Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1) Shishkov, S. Varadinova, T. Panteva, M. Bontchev, P. Met Based Drugs Research Article Our previous results show that Zn(pic)(2) and Zn(asp)(2) inhibit key steps of the replication of HSV-1. Anti-HSV effect of complexes of Co(II) with aminoacids Lys and Ser was also found. In the present study we describe the effect of complexes of Zn(II), Co(II) and Cu(II) with D-aminosugars on the replication of HSV-1 and on the infectivity of free virions. The experiments were done using primary rabbit kidney cells (r.k.), diploid human embryonal fibroblasts (F) and Vero cells. No differences in the toxicity of metal complexes on diploid cells- r.k. and F, were found. Neither metal complexes, nor ligands-galactosoxime and glucosoxime, influenced the viral replication. During 1-4h prolonged contact only Cu(Gl.NOH)(2) inactivated HSV-1 virions up to 90%. The results show that D-aminosugars are not suitable ligands for Zn(II), Cu(II) and Co(II) in respect of the inhibition of viral replication. However, only Cu(Gl.NOH)(2) was able to inhibit the infectivity of free virions. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2365038/ /pubmed/18475763 http://dx.doi.org/10.1155/MBD.1997.35 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shishkov, S.
Varadinova, T.
Panteva, M.
Bontchev, P.
Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1)
title Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1)
title_full Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1)
title_fullStr Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1)
title_full_unstemmed Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1)
title_short Effect of Complexes of Zinc, Cobalt and Copper With D-Aminosugars on the Replication of Herpes Simplex Virus Type 1 (HSV-1)
title_sort effect of complexes of zinc, cobalt and copper with d-aminosugars on the replication of herpes simplex virus type 1 (hsv-1)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365038/
https://www.ncbi.nlm.nih.gov/pubmed/18475763
http://dx.doi.org/10.1155/MBD.1997.35
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