Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones

Nickel(II) complexes of thiosemicarbazons were observed to be potent cytotoxic agents in human and rodent tissue cultured tumor cells. Each compound demonstrated a slightly different profile in the various histological types of tumors. The nickel complex of Appip demonstrated the most potent in vivo...

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Autores principales: Hall, Iris H., Miller, Merrill C., West, Douglas X.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365044/
https://www.ncbi.nlm.nih.gov/pubmed/18475774
http://dx.doi.org/10.1155/MBD.1997.89
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author Hall, Iris H.
Miller, Merrill C.
West, Douglas X.
author_facet Hall, Iris H.
Miller, Merrill C.
West, Douglas X.
author_sort Hall, Iris H.
collection PubMed
description Nickel(II) complexes of thiosemicarbazons were observed to be potent cytotoxic agents in human and rodent tissue cultured tumor cells. Each compound demonstrated a slightly different profile in the various histological types of tumors. The nickel complex of Appip demonstrated the most potent in vivo activity in the Ehrlich ascites carcinoma. This agent selectively inhibited L1210 DNA and purine syntheses, and DNA polymerase α, PRPP-amido transferase, IMP-dehydrogenase, dihydrofolate reductase, TMP-kinase and thymidylate synthetase activities. L1210 DNA strand scission was evident and DNA viscosity was reduced after 24 hr incubation. The nickel complexes were not L1210 DNA topoisomerase II inhibitors.
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spelling pubmed-23650442008-05-12 Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones Hall, Iris H. Miller, Merrill C. West, Douglas X. Met Based Drugs Research Article Nickel(II) complexes of thiosemicarbazons were observed to be potent cytotoxic agents in human and rodent tissue cultured tumor cells. Each compound demonstrated a slightly different profile in the various histological types of tumors. The nickel complex of Appip demonstrated the most potent in vivo activity in the Ehrlich ascites carcinoma. This agent selectively inhibited L1210 DNA and purine syntheses, and DNA polymerase α, PRPP-amido transferase, IMP-dehydrogenase, dihydrofolate reductase, TMP-kinase and thymidylate synthetase activities. L1210 DNA strand scission was evident and DNA viscosity was reduced after 24 hr incubation. The nickel complexes were not L1210 DNA topoisomerase II inhibitors. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2365044/ /pubmed/18475774 http://dx.doi.org/10.1155/MBD.1997.89 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hall, Iris H.
Miller, Merrill C.
West, Douglas X.
Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones
title Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones
title_full Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones
title_fullStr Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones
title_full_unstemmed Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones
title_short Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones
title_sort antineoplastic and cytotoxic activities of nickel(ii) complexes of thiosemicarbazones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365044/
https://www.ncbi.nlm.nih.gov/pubmed/18475774
http://dx.doi.org/10.1155/MBD.1997.89
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