Fe-EDTA-Bisamide and Fe-ADR-925, The Iron-Bound Hydrolysis Product of the Cardioprotective Agent Dexrazoxane, Cleave DNA Via the Hydroxyl Radical

Use of the antitumor drug doxorubicin is limited by cardiomyopathic side-effects which are believed to be due to iron-mediated hydroxyl radical generation. Dexrazoxane reduces this cardiotoxicity, possibly by removal of iron from doxorubicin by the EDTA-like hydrolysis product of dexrazoxane, ADR-92...

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Detalles Bibliográficos
Autores principales: Magliery, Thomas J., Vitellaro, Lizabeth K., Diop, Ndeye Khady, Marusak, Rosemary A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365068/
https://www.ncbi.nlm.nih.gov/pubmed/18475789
http://dx.doi.org/10.1155/MBD.1997.199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365068/
https://www.ncbi.nlm.nih.gov/pubmed/18475789
http://dx.doi.org/10.1155/MBD.1997.199

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