Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes

The modulation of radiation induced lipid peroxidation in synaptosomes by iron (II) and iron (III) complexes of two naturally occurring and therapeutically relevant naphthoquinones viz. 5,hydroxy-1,4 naphthoquinone; juglone and 2,hydroxy-1,4 naphthoquinone; lawsone, have been studied. At lower conce...

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Detalles Bibliográficos
Autores principales: Kumbhar, A. S., Padhye, S. B., Jitender, Kale, R. K.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365073/
https://www.ncbi.nlm.nih.gov/pubmed/18475800
http://dx.doi.org/10.1155/MBD.1997.279
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author Kumbhar, A. S.
Padhye, S. B.
Jitender
Kale, R. K.
author_facet Kumbhar, A. S.
Padhye, S. B.
Jitender
Kale, R. K.
author_sort Kumbhar, A. S.
collection PubMed
description The modulation of radiation induced lipid peroxidation in synaptosomes by iron (II) and iron (III) complexes of two naturally occurring and therapeutically relevant naphthoquinones viz. 5,hydroxy-1,4 naphthoquinone; juglone and 2,hydroxy-1,4 naphthoquinone; lawsone, have been studied. At lower concentrations the complexes enhance lipid peroxidation predominantly through redox cycling as observed for Fe(II)- juglonate while at higher concentrations the complexes tend to limit lipid peroxidation through fast recombinations.
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spelling pubmed-23650732008-05-12 Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes Kumbhar, A. S. Padhye, S. B. Jitender Kale, R. K. Met Based Drugs Research Article The modulation of radiation induced lipid peroxidation in synaptosomes by iron (II) and iron (III) complexes of two naturally occurring and therapeutically relevant naphthoquinones viz. 5,hydroxy-1,4 naphthoquinone; juglone and 2,hydroxy-1,4 naphthoquinone; lawsone, have been studied. At lower concentrations the complexes enhance lipid peroxidation predominantly through redox cycling as observed for Fe(II)- juglonate while at higher concentrations the complexes tend to limit lipid peroxidation through fast recombinations. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2365073/ /pubmed/18475800 http://dx.doi.org/10.1155/MBD.1997.279 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kumbhar, A. S.
Padhye, S. B.
Jitender
Kale, R. K.
Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes
title Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes
title_full Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes
title_fullStr Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes
title_full_unstemmed Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes
title_short Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes
title_sort naturally occurring hydroxy napthoquinones and their iron complexes as modulators of radiation induced lipid peroxidation in synaptosomes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365073/
https://www.ncbi.nlm.nih.gov/pubmed/18475800
http://dx.doi.org/10.1155/MBD.1997.279
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