Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate

The rhodium (II) complexes Rh(2)(tfa)(4).2(tfac) and Rh(2)(tfacam)(4) (tfacam = CF(3)CONH-,tfa = CF(3)COO-,tfac = CF(3)CONH(2)) were synthesized and characterized by microanalysis and electronic and vibrational spectroscopies. Rh(2)(tfacam)(4) was tested both in vitro (U937 and K562 human leukemia c...

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Detalles Bibliográficos
Autores principales: Espósito, Breno Pannia, Zyngier, Szulim Ber, de Souza, Aparecido Ribeiro, Najjar, Renato
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365087/
https://www.ncbi.nlm.nih.gov/pubmed/18475814
http://dx.doi.org/10.1155/MBD.1997.333
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author Espósito, Breno Pannia
Zyngier, Szulim Ber
de Souza, Aparecido Ribeiro
Najjar, Renato
author_facet Espósito, Breno Pannia
Zyngier, Szulim Ber
de Souza, Aparecido Ribeiro
Najjar, Renato
author_sort Espósito, Breno Pannia
collection PubMed
description The rhodium (II) complexes Rh(2)(tfa)(4).2(tfac) and Rh(2)(tfacam)(4) (tfacam = CF(3)CONH-,tfa = CF(3)COO-,tfac = CF(3)CONH(2)) were synthesized and characterized by microanalysis and electronic and vibrational spectroscopies. Rh(2)(tfacam)(4) was tested both in vitro (U937 and K562 human leukemia cells and Ehrlich ascitic tumor cells) and in vivo for cytostatic activity and lethal dose determination, respectively. This is the first rhodium tetra-amidate to have its biological activity evaluated. The LD(50) value for Rh(2)(tfacam)(4) is of the same order as that of cisplatin, and it was verified that the rhodium complex usually needs lower doses than cisplatin to promote the same inhibitory effects.
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spelling pubmed-23650872008-05-12 Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate Espósito, Breno Pannia Zyngier, Szulim Ber de Souza, Aparecido Ribeiro Najjar, Renato Met Based Drugs Research Article The rhodium (II) complexes Rh(2)(tfa)(4).2(tfac) and Rh(2)(tfacam)(4) (tfacam = CF(3)CONH-,tfa = CF(3)COO-,tfac = CF(3)CONH(2)) were synthesized and characterized by microanalysis and electronic and vibrational spectroscopies. Rh(2)(tfacam)(4) was tested both in vitro (U937 and K562 human leukemia cells and Ehrlich ascitic tumor cells) and in vivo for cytostatic activity and lethal dose determination, respectively. This is the first rhodium tetra-amidate to have its biological activity evaluated. The LD(50) value for Rh(2)(tfacam)(4) is of the same order as that of cisplatin, and it was verified that the rhodium complex usually needs lower doses than cisplatin to promote the same inhibitory effects. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2365087/ /pubmed/18475814 http://dx.doi.org/10.1155/MBD.1997.333 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Espósito, Breno Pannia
Zyngier, Szulim Ber
de Souza, Aparecido Ribeiro
Najjar, Renato
Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate
title Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate
title_full Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate
title_fullStr Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate
title_full_unstemmed Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate
title_short Rh(2)(CF(3)CONH)(4): The First Biological Assays of a Rhodium (II) Amidate
title_sort rh(2)(cf(3)conh)(4): the first biological assays of a rhodium (ii) amidate
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365087/
https://www.ncbi.nlm.nih.gov/pubmed/18475814
http://dx.doi.org/10.1155/MBD.1997.333
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